Puerarin

Puerarin, one of several known isoflavones, is found in a number of plants and herbs, such as the root of Pueraria (Radix puerariae)[1] notably of the kudzu plant.

Puerarin
Names
IUPAC name
7-Hydroxy-3-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
Other names
Daidzein-8-C-glucoside
7,4'-Dihydroxy-8-C-glucosylisoflavone
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.130.674
UNII
Properties
C21H20O9
Molar mass 416.382 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Puerarin is the 8-C-glucoside of daidzein.[2]

List of plants that contain the chemical

Notes and references
  1. Dennis K.Y. Yeunga; Susan W.S. Leung; Yan Chun Xua; Paul M. Vanhouttea; Ricky Y.K. Mana (2006). "Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery". European Journal of Pharmacology. 552 (1–3): 105–11. doi:10.1016/j.ejphar.2006.08.078. PMID 17027964.
  2. Overstreet DH, Kralic JE, Morrow AL, Ma ZZ, Zhang YW, Lee DY (2003). "NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists". Pharmacology Biochemistry and Behavior. 75 (3): 619–625. doi:10.1016/S0091-3057(03)00114-X. PMID 12895679. S2CID 22252214.
  3. Wang, Lingzhao; Yang, BAO; Du, Xiuqiao; et al. (2009). "Investigation of supercritical fluid extraction of puerarin from Pueraria Lobata". Journal of Food Process Engineering. John Wiley & Sons. 32 (5): 682–691. doi:10.1111/j.1745-4530.2007.00238.x.
  4. Chen, Gang; Zhang, J; Ye, J; et al. (2001). "Determination of puerarin, daidzein and rutin in Pueraria lobata (Wild.) Ohwi by capillary electrophoresis with electrochemical detection". Journal of Chromatography A. Elsevier. 923 (1–2): 255–262. doi:10.1016/S0021-9673(01)00996-7. PMID 11510548.
  5. Kintzios, Spiridon; Makri, Olga; Pistola, Eleni; Matakiadis, Theodoros; Ping Shi, He; Economou, Athanassios; et al. (2004). "Scale-up production of puerarin from hairy roots of Pueraria phaseoloides in an airlift bioreactor". Biotechnology Letters. Springer. 26 (13): 1057–1059. doi:10.1023/B:BILE.0000032963.41208.e8. ISSN 0141-5492. S2CID 23425268.
  6. Shi, H. P; S. Kintzies (2003). "Genetic transformation of Pueraria phaseoloides with Agrobacterium rhizogenes and puerarin production in hairy roots". Plant Cell Reports. Springer. 21 (11): 1103–1107. doi:10.1007/s00299-003-0633-6. ISSN 0721-7714. PMID 12836005. S2CID 21825544.


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