Fructose-2,6-bisphosphate 2-phosphatase

In enzymology, a fructose-2,6-bisphosphate 2-phosphatase (EC 3.1.3.46) is an enzyme that catalyzes the chemical reaction

beta-D-fructose 2,6-bisphosphate + H2O D-fructose 6-phosphate + phosphate
fructose-2,6-bisphosphate 2-phosphatase
Identifiers
EC number3.1.3.46
CAS number81611-75-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are beta-D-fructose 2,6-bisphosphate and H2O, whereas its two products are D-fructose 6-phosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase. Other names in common use include fructose-2,6-bisphosphatase, and D-fructose-2,6-bisphosphate 2-phosphohydrolase. This enzyme participates in fructose and mannose metabolism.

Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1BIF, 1C7Z, 1C80, 1C81, 1FBT, 1K6M, 1TIP, 2AXN, 2BIF, 2DWO, 2DWP, 2I1V, and 3BIF.

References

    • van Schaftingen E, Davies DR, Hers HG (1982). "Fructose-2,6-bisphosphatase from rat liver". Eur. J. Biochem. 124 (1): 143–9. doi:10.1111/j.1432-1033.1982.tb05917.x. PMID 6282585.


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