Licodione synthase
In enzymology, a licodione synthase (EC 1.14.13.87) is an enzyme that catalyzes the chemical reaction
- liquiritigenin + NADPH + H+ + O2 licodione + NADP+ + H2O
| Licodione synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.87 | ||||||||
| CAS number | 157972-05-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The 4 substrates of this enzyme are liquiritigenin, NADPH, H+, and O2, whereas its 3 products are licodione, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming).
References
- Otani K, Takahashi T, Furuya T, Ayabe S (1994). "Licodione Synthase, a Cytochrome P450 Monooxygenase Catalyzing 2-Hydroxylation of 5-Deoxyflavanone, in Cultured Glycyrrhiza echinata L. Cells". Plant Physiol. 105 (4): 1427–1432. doi:10.1104/pp.105.4.1427. PMC 159476. PMID 12232298.
- Akashi T, Aoki T, Ayabe S (1998). "Identification of a cytochrome P450 cDNA encoding (2S)-flavanone 2-hydroxylase of licorice (Glycyrrhiza echinata L.; Fabaceae) which represents licodione synthase and flavone synthase II". FEBS Lett. 431 (2): 287–90. doi:10.1016/S0014-5793(98)00781-9. PMID 9708921.
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