Monoterpene epsilon-lactone hydrolase

Monoterpene epsilon-lactone hydrolase (EC 3.1.1.83, MLH) is an enzyme with systematic name isoprop(en)ylmethyloxepan-2-one lactonohydrolase.[1] This enzyme catalyses the following chemical reaction

(1) isoprop(en)ylmethyloxepan-2-one + H2O 6-hydroxyisoprop(en)ylmethylhexanoate (general reaction)
(2) 4-isopropenyl-7-methyloxepan-2-one + H2O 6-hydroxy-3-isopropenylheptanoate
(3) 7-isopropyl-4-methyloxepan-2-one + H2O 6-hydroxy-3,7-dimethyloctanoate
Monoterpene epsilon-lactone hydrolase
Identifiers
EC number3.1.1.83
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme catalyses the ring opening of epsilon-lactones in Gram-positive bacterium Rhodococcus erythropolis DCL14.

References

  1. van der Vlugt-Bergmans CJ, van der Werf MJ (February 2001). "Genetic and biochemical characterization of a novel monoterpene epsilon-lactone hydrolase from Rhodococcus erythropolis DCL14". Applied and Environmental Microbiology. 67 (2): 733–41. doi:10.1128/aem.67.2.733-741.2001. PMC 92642. PMID 11157238.
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