Myristoyl-CoA 11-(Z) desaturase
In enzymology, a myristoyl-CoA 11-(Z) desaturase (EC 1.14.99.32) is an enzyme that catalyzes the chemical reaction
- myristoyl-CoA + NAD(P)H + H+ + O2 (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O
| myristoyl-CoA 11-(Z) desaturase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.99.32 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 5 substrates of this enzyme are myristoyl-CoA, NADH, NADPH, H+, and O2, whereas its 4 products are (Z)-11-tetradecenoyl-CoA, NAD+, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(Z) desaturating]. This enzyme is also called n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(Z) desaturating].
References
- Navaro I, Font I, Fabrias G, Camps F (1997). "Stereospecificity of the (E)- and (Z)-11 myristoyl desaturases in the biosynthesis of Spodoptera littoralis sex pheromone". J. Am. Chem. Soc. 119 (46): 11335–11336. doi:10.1021/ja972577v.
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