Orthostatic intolerance

Orthostatic intolerance is divided, roughly based on patient history, in two variants: acute and chronic.

Symptoms of OI are triggered by the following:

• An upright posture for long periods of time (e.g. standing in line, standing in a shower, or even sitting at a desk).
• A warm environment (such as in hot summer weather, a hot crowded room, a hot shower or bath, after exercise).
• Emotionally stressful events (seeing blood or gory scenes, being scared or anxious).
• Astronauts returning from space not yet re-adapted to gravity.[7]
• Extended bedrest[7]
• Inadequate fluid and salt intake.[4]

OI is "notoriously difficult to diagnose."[8] As a result, many patients have gone undiagnosed or misdiagnosed and either untreated or treated for other disorders. Current tests for OI (Tilt table test, autonomic assessment, and vascular integrity) can also specify and simplify treatment.[6]

Most patients experience an improvement of their symptoms, but for some, OI can be gravely disabling and can be progressive in nature, particularly if it is caused by an underlying condition which is deteriorating. The ways in which symptoms present themselves vary greatly from patient to patient; as a result, individualized treatment plans are necessary.[9]

OI is treated both pharmacologically and non-pharmacologically. Treatment does not cure OI; rather, it controls symptoms.

Physicians who specialize in treating OI agree that the single most important treatment is drinking more than two liters (eight cups) of fluids each day. A steady, large supply of water or other fluids reduces most, and for some patients all, of the major symptoms of this condition. Typically, patients fare best when they drink a glass of water no less frequently than every two hours during the day, instead of drinking a large quantity of water at a single point in the day.[4]

For most severe cases and some milder cases, a combination of medications are used. Individual responses to different medications vary widely, and a drug which dramatically improves one patient's symptoms may make another patient's symptoms much worse. Medications focus on three main issues:[4]

Medications that increase blood volume:

• Fludrocortisone (Florinef)
• Erythropoietin
• Hormonal contraception

Medications that inhibit acetylcholinesterase:

• Pyridostigmine

Medications that improve vasoconstriction:

• Stimulants: (e.g., Ritalin or Dexedrine)
• Midodrine (ProAmatine)
• Ephedrine and pseudoephedrine (Sudafed)
• Theophylline (low-dose)
• Selective serotonin reuptake inhibitors (SSRI's - Prozac, Zoloft, and Paxil)

Behavioral changes that patients with OI can make are:

• Avoiding triggers such as prolonged sitting, quiet standing, warm environments, or vasodilating medications
• Using postural maneuvers and pressure garments
• Treating co-existing medical conditions
• Increasing fluid and salt intake
• Physical therapy and exercise[4]

A notable sufferer of OI is Greg Page, founding member and original lead singer of the Australian children's music group The Wiggles. It was due to being diagnosed with this illness that Page left the group in 2006 and was replaced by his understudy Sam Moran.[8][10] Two years later, he went on to create his own fund for OI to help fund research into this then little known disorder.[11] Page recovered sufficiently enough to temporarily return to The Wiggles in 2012 to help with the transition to the next generation of Wiggles, after which he again left the group and was replaced by Emma Watkins.[12]

• Orthostatic hypertension
• Orthostatic hypotension
• Postural orthostatic tachycardia syndrome (POTS)
• Vasovagal response