Phenylacetyl-CoA hydrolase
In enzymology, a phenylacetyl-CoA hydrolase (EC 3.1.2.25) is an enzyme that catalyzes the chemical reaction
- phenylglyoxylyl-CoA + H2O phenylglyoxylate + CoA
| Phenylacetyl-CoA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.2.25 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are phenylglyoxylyl-CoA and H2O, whereas its two products are phenylglyoxylate and CoA.
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is phenylglyoxylyl-CoA hydrolase.
References
- Rhee SK, Fuchs G (1999). "Phenylacetyl-CoA:acceptor oxidoreductase, a membrane-bound molybdenum-iron-sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica". Eur. J. Biochem. 262 (2): 507–15. doi:10.1046/j.1432-1327.1999.00399.x. PMID 10336636.
- Schneider S, Fuchs G (1998). "Phenylacetyl-CoA:acceptor oxidoreductase, a new alpha-oxidizing enzyme that produces phenylglyoxylate. Assay, membrane localization, and differential production in Thauera aromatica". Arch. Microbiol. 169 (6): 509–16. doi:10.1007/s002030050604. PMID 9575237.
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