Porfimer sodium

Porfimer sodium
Clinical data
AHFS/Drugs.com	Consumer Drug Information
License data	EU EMA: by INN; US FDA: Photofrin;
Routes of; administration	Intravenous
ATC code	L01XD01 (WHO) ;
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	NA
Protein binding	~90%
Elimination half-life	21.5 days (mean)
Excretion	Fecal
Identifiers
CAS Number	87806-31-3 ; ethyl ether: 97067-70-4 ;
PubChem CID	57166;
DrugBank	DB00707 ;
ChemSpider	10482283 ;
UNII	Y3834SIK5F; ethyl ether: 625J2HS54G ;
ChEMBL	ChEMBL1201707 ;
Chemical and physical data
Formula	C68H74N8O11 (for n=0)
Molar mass	1179.36 g/mol (for n=0) g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Na+].CC(O)C1=C(C)C=2C=C5NC(=CC4=NC(=CC=3NC(C=C1N=2)=C(C)C=3CCC(O)=O)C(CCC(O)=O)=C4C)C(C)=C5C(C)OC(C)C6=C(C)C=7C=C%10NC(=CC9=NC(=CC=8NC(C=C6N=7)=C(C)C=8CCC(O)=O)C(CCC(O)=O)=C9C)C(C)=C%10C(C)O;
	InChI InChI=1S/C68H74N8O11.Na/c1-29-41(13-17-61(79)80)53-28-56-44(16-20-64(85)86)32(4)48(72-56)24-59-68(36(8)52(76-59)25-58-65(37(9)77)33(5)49(73-58)21-45(29)69-53)40(12)87-39(11)67-35(7)50-22-46-30(2)42(14-18-62(81)82)54(70-46)27-55-43(15-19-63(83)84)31(3)47(71-55)23-57-66(38(10)78)34(6)51(74-57)26-60(67)75-50;/h21-28,37-40,71-73,75,77-78H,13-20H2,1-12H3,(H,79,80)(H,81,82)(H,83,84)(H,85,86);/q;+1/b45-21-,46-22-,47-23-,48-24-,49-21-,50-22-,51-26-,52-25-,53-28-,54-27-,55-27-,56-28-,57-23-,58-25-,59-24-,60-26-; ; Key:CGQHMICGJYKFFJ-ZLJVSRBASA-N ;
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Porfimer sodium, sold as Photofrin, is a photosensitizer used in photodynamic therapy and radiation therapy and for palliative treatment of obstructing endobronchial non-small cell lung carcinoma and obstructing esophageal cancer.

Porfimer is a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units.[1] In practice, a red light source emitting at 630 nm is used to excite the Porfimer oligomers.[2]

Porfimer is Haematoporphyrin Derivative (HpD) (See PDT).

Approvals and indications

It was approved in Canada in 1993 for the treatment of bladder cancer.[2] It was approved in Japan in 1994 (for early stage lung cancer?).[2] It was approved by the U.S. FDA in December 1995 for esophageal cancer, and in 1998, it was approved for the treatment of early non-small cell lung cancer.[2]

In August 2003 the FDA approved its use for Barrett's esophagus.[3]

References

"Porfimer injection Prescribing information" (PDF).
Usuda J, Kato H, Okunaka T, Furukawa K, Tsutsui H, Yamada K, et al. (June 2006). "Photodynamic therapy (PDT) for lung cancers". Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. 1 (5): 489–93. doi:10.1016/S1556-0864(15)31616-6. PMID 17409904.
"FDA Patient Safety News: Show #20, October 2003". October 2003. Retrieved 2009-08-17.

External links

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[1] "Porfimer injection Prescribing information" (PDF).

[Usuda_2006-2] Usuda J, Kato H, Okunaka T, Furukawa K, Tsutsui H, Yamada K, et al. (June 2006). "Photodynamic therapy (PDT) for lung cancers". Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. 1 (5): 489–93. doi:10.1016/S1556-0864(15)31616-6. PMID 17409904.

[3] "FDA Patient Safety News: Show #20, October 2003". October 2003. Retrieved 2009-08-17.