Proteins produced and secreted by the liver

The liver plays the major role in producing proteins that are secreted into the blood, including major plasma proteins, factors in hemostasis and fibrinolysis, carrier proteins, hormones, prohormones and apolipoprotein:

Major plasma proteins

Factors in hemostasis and fibrinolysis

  • Stimulators of coagulation:
    • All factors in the coagulation cascade.[2]
    • While the endothelium does produce some factor VIII, the majority of factor VIII is produced in the liver.[3]
  • Inhibitors of coagulation: Inactivate an enormous variety of proteinases
  • Fibrinolysis: Breakdown of fibrin clots
  • Inhibitors of fibrinolysis
    • α2-antiplasmin
  • Complement components C1-9, complement component 3 (C3)

Carrier proteins

Hormones

Prohormones

  • Angiotensinogen, when converted to angiotensin causes vasoconstriction and release of aldosterone, in effect increasing blood pressure

Apolipoproteins

References

General reference for the list of included substances (but not their functions):

  • Table 45-4 in: Walter F., PhD. Boron (2003). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. p. 1300. ISBN 1-4160-2328-3.

Other:

  1. Lippincott's Illustrated Reviews: Immunology. Paperback: 384 pages. Publisher: Lippincott Williams & Wilkins; (July 1, 2007). Language: English. ISBN 978-0-7817-9543-2. Page 182
  2. BRS Pathology 5th Edition, pg. 196
  3. Robbins Basic Pathology 9th Edition, Chapter 11
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