Retinyl-palmitate esterase

In enzymology, a retinyl-palmitate esterase (EC 3.1.1.21) is an enzyme that catalyzes the chemical reaction

retinyl palmitate + H2O retinol + palmitate
retinyl-palmitate esterase
Identifiers
EC number3.1.1.21
CAS number9063-69-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are retinyl palmitate and H2O, whereas its two products are retinol and palmitate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is retinyl-palmitate palmitohydrolase. Other names in common use include retinyl palmitate hydrolase, retinyl palmitate hydrolyase, and retinyl ester hydrolase. This enzyme participates in retinol metabolism.

References

    • Mahadevan S, Ayyoub NI, Roels OA (1966). "Hydrolysis of retinol palmitate by rat liver". J. Biol. Chem. 241 (1): 57–64. PMID 5901057.


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