Ribonuclease 4

RNASE4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RNF, 2RNF
Identifiers
Aliases	RNASE4, RAB1, RNS4, Ribonuclease 4, ribonuclease A family member 4
External IDs	OMIM: 601030 MGI: 1926217 HomoloGene: 10576 GeneCards: RNASE4
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	20,701,216 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	51,106,151 bp[2]
Gene ontology
Molecular function	• nuclease activity; • endonuclease activity; • ribonuclease activity; • hydrolase activity; • ribonuclease A activity; • nucleic acid binding;
Cellular component	• extracellular region;
Biological process	• mRNA cleavage; • RNA phosphodiester bond hydrolysis, endonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	6038
	58809
	ENSG00000258818
	ENSMUSG00000021876
	P34096
	Q9JJH1; Q8C7E4
	NM_194431; NM_001282192; NM_001282193; NM_002937; NM_194430
	NM_021472; NM_201239
	NP_001269121; NP_001269122; NP_002928; NP_919412
	NP_067447; NP_957691
	Wikidata
View/Edit Human	View/Edit Mouse

Ribonuclease 4 is an enzyme that in humans is encoded by the RNASE4 gene.[5][6]

The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides.

Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.[6]

References

GRCh38: Ensembl release 89: ENSG00000258818 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021876 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Rosenberg HF, Dyer KD (Jan 1996). "Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues". Nucleic Acids Res. 23 (21): 4290–5. doi:10.1093/nar/23.21.4290. PMC 307382. PMID 7501448.
"Entrez Gene: RNASE4 ribonuclease, RNase A family, 4".

Shapiro R, Fett JW, Strydom DJ, Vallee BL (1987). "Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity". Biochemistry. 25 (23): 7255–64. doi:10.1021/bi00371a002. PMID 3467790.
Seno M, Futami J, Tsushima Y, et al. (1995). "Molecular cloning and expression of human ribonuclease 4 cDNA". Biochim. Biophys. Acta. 1261 (3): 424–6. doi:10.1016/0167-4781(95)00040-n. PMID 7742370.
Zhou HM, Strydom DJ (1993). "The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine". Eur. J. Biochem. 217 (1): 401–10. doi:10.1111/j.1432-1033.1993.tb18259.x. PMID 8223579.
Egesten A, Dyer KD, Batten D, et al. (1997). "Ribonucleases and host defense: identification, localization and gene expression in adherent monocytes in vitro". Biochim. Biophys. Acta. 1358 (3): 255–60. doi:10.1016/S0167-4889(97)00081-5. PMID 9366257.
Terzyan SS, Peracaula R, de Llorens R, et al. (1999). "The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity". J. Mol. Biol. 285 (1): 205–14. doi:10.1006/jmbi.1998.2288. PMID 9878400.
Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000258818 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021876 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7501448-5] Rosenberg HF, Dyer KD (Jan 1996). "Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues". Nucleic Acids Res. 23 (21): 4290–5. doi:10.1093/nar/23.21.4290. PMC 307382. PMID 7501448.

[entrez-6] "Entrez Gene: RNASE4 ribonuclease, RNase A family, 4".

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Ribonuclease 4

References

Further reading