Ro 3-0419
Ro 3-0419 is a highly toxic organophosphate acetylcholinesterase inhibitor. It's the neutral analog of Ro 3-0422. Although Ro 3-0419 is less potent than Ro 3-0422, it does not have a positively charged nitrogen atom, so it's able to cross the blood brain barrier to inhibit cholinesterases in the brain. The intravenous LD50 of Ro 3-0419 is 1 mg/kg in mice.[1]
 | |
| Names | |
|---|---|
| IUPAC name
Diethyl 3-quinolinyl phosphate | |
| Other names
3-(Diethoxyphosphinyloxy)-quinoline | |
| Identifiers | |
3D model (JSmol) |
|
| ChemSpider | |
PubChem CID |
|
| |
| |
| Properties | |
| C13H16NO4P | |
| Molar mass | 281.248 g·mol−1 |
| Hazards | |
| Main hazards | Highly toxic |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose) |
1 mg/kg (mice, intravenous) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
See also
References
- HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base". British Journal of Pharmacology and Chemotherapy. 9 (2): 159–65. doi:10.1111/j.1476-5381.1954.tb00835.x. PMC 1509437. PMID 13172424.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.