Tocofersolan

Tocofersolan
Clinical data
Trade names	Vedrop
Other names	Tocophersolan (USAN US)
AHFS/Drugs.com	UK Drug Information
Legal status
Legal status	UK: POM (Prescription only) [1]; EU: Rx-only [2];
Identifiers
DrugBank	DB11635;
KEGG	D06174;
CompTox Dashboard (EPA)	DTXSID90872278 DTXSID1048623, DTXSID90872278 ;
ECHA InfoCard	100.123.651

Tocofersolan
Names
	IUPAC name α-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-poly(oxy-1,2-ethanediyl)
	Other names Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate (TPGS); Liqui-E
Identifiers
CAS Number	9002-96-4 ;
3D model (JSmol)	Interactive image;
ChemSpider	64498 ;
ECHA InfoCard	100.123.651
PubChem CID	9938056;
UNII	O03S90U1F2 ;
CompTox Dashboard (EPA)	DTXSID90872278 DTXSID1048623, DTXSID90872278 ;
	InChI InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3 Key: AOBORMOPSGHCAX-UHFFFAOYSA-N ; InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3 Key: AOBORMOPSGHCAX-UHFFFAOYAU;
	SMILES O=C(OCCO)CCC(=O)Oc2c(c(c1OC(CCc1c2C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)C;
Properties
Chemical formula	(C2H4O)nC33H54O5
Molar mass	Variable
Pharmacology
ATC code	A11HA08 (WHO)
License data	EU EMA: by INN;
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Tocofersolan (INN) or tocophersolan, commonly referred to as TPGS, is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of α-tocopherol that enables water solubility.

Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease.[3] On 24 July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients suffering from congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).[4]

Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.[5]

References

"Vedrop 50 mg/ml oral solution - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Retrieved 24 July 2020.
"Vedrop EPAR". European Medicines Agency (EMA). Retrieved 24 July 2020.
"Tocophersolan Oral". WebMD.
"Vedrop Summary of Product Characteristics" (PDF). European Medicines Agency.
Ash M, Ash I (2004). Handbook of Preservatives. p. 568. ISBN 1-890595-66-7.

External links

"Tocophersolan". Drug Information Portal. U.S. National Library of Medicine.

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[1] "Vedrop 50 mg/ml oral solution - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Retrieved 24 July 2020.

[2] "Vedrop EPAR". European Medicines Agency (EMA). Retrieved 24 July 2020.

[3] "Tocophersolan Oral". WebMD.

[4] "Vedrop Summary of Product Characteristics" (PDF). European Medicines Agency.

[5] Ash M, Ash I (2004). Handbook of Preservatives. p. 568. ISBN 1-890595-66-7.