Trequinsin
Trequinsin is a phosphodiesterase inhibitor.[1] It has been shown to improve sperm motility in vitro.[2]
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| IUPAC name
9,10-Dimethoxy-3-methyl-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one | |
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3D model (JSmol) |
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CompTox Dashboard (EPA) |
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| Properties | |
| C24H27N3O3 | |
| Molar mass | 405.498 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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References
- Whitaker, RM; Wills, LP; Stallons, LJ; Schnellmann, RG (2013). "CGMP-Selective Phosphodiesterase Inhibitors Stimulate Mitochondrial Biogenesis and Promote Recovery from Acute Kidney Injury". The Journal of Pharmacology and Experimental Therapeutics. 347 (3): 626–34. doi:10.1124/jpet.113.208017. PMC 3836317. PMID 24042162.
- McBrinn RC, Fraser J, Hope AG, Gray DW, Barratt CLR, Martins da Silva SJ, Brown SG. Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function. Br J Pharmacol. 2019 Dec;176(23):4521-4536. doi:10.1111/bph.14814 PMID 31368510
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