Warren Alpert Foundation Prize

The Warren Alpert Foundation Prize is awarded annually to scientist(s) whose scientific achievements have led to the prevention, cure or treatment of human diseases or disorders, and/or whose research constitutes a seminal scientific finding that holds great promise of ultimately changing our understanding of or ability to treat disease. The prize was established in 1987 by the late philanthropist and businessman Warren Alpert[1] and the Warren Alpert Foundation.

The Warren Alpert Prize is given internationally and since its inception, 10 winners have gone on to win Nobel Prizes.[2]

The prize is administered in concert with Harvard Medical School in Boston, Massachusetts and the Warren Alpert Foundation, located in Providence, Rhode Island. An annual symposium is held at Harvard Medical School each fall where the recipient(s) present their work. The prize currently includes $500,000,[3] a citation and plaque.

Warren Alpert Foundation Prize Recipients
YearRecipient(s)CitationNationality
2020Daniel Drucker, Joel Habener, Jens Juul Holst For identifying Glucagon-like peptides and leading the field with studies extending from cells to humans, culminating in the development of these peptides as therapeutic agents for treating diabetes and short bowel syndrome. [4]  Canada United States

 Denmark

2019 Ed Boyden, Karl Deisseroth, Peter Hegemann, Gero Miesenböck For pioneering work in the field of optogenetics, a revolutionary technique that uses light and genetic modification to control the activity of cells in the brain.  United States

 Germany

 Austria

2018Francis Collins, Paul Negulescu, Bonnie Ramsey, Lap-Chee Tsui, Michael WelshFor identifying faulty gene behind devastating disease, development of precision-targeted therapies United States China
2017Arlene Sharpe, Harvard Medical School, Gordon Freeman, Dana Farber Cancer Institute, Lieping Chen, Yale University, James P. Allison, University of Texas M.D. Anderson Cancer Center, Tasuku Honjo, Kyoto UniversityFor their collective contributions to the pre-clinical foundation and development of immune checkpoint blockade, a novel form of cancer therapy that has transformed the landscape of cancer treatment.[3] United States Japan
2016Rodolphe Barrangou, North Carolina State University, Philippe Horvath, DuPont, Jennifer Doudna, University of California, Berkeley, Emmanuelle Charpentier, Max Planck Institute for Infection Biology and Umeå University, Virginijus Šikšnys, Vilnius University Institute of BiotechnologyFor their remarkable contributions to the understanding of the CRISPR bacterial defense system and the revolutionary discovery that it can be adapted for genome editing [5] France United States

 Lithuania

2015Ruth Sonntag Nussenzweig and Victor Nussenzweig, NYU Langone Medical Center, Tu Youyou of the China Academy of Chinese Medical Sciences, BeijingFor their pioneering discoveries in chemistry and parasitology, and their personal commitment to translating these discoveries into effective chemotherapeutic and vaccine-based approaches to controlling malaria[6] Brazil

 China

2014Dr. Oleh Hornykiewicz, Medical University of Vienna, Roger A. Nicoll, University of California, San Francisco, Dr. Solomon H. Snyder, Johns Hopkins School of MedicineFor seminal contributions to our understanding of neurotransmission and neurodegeneration.[7][8] Austria  United States
2013Dr. David Botstein, Princeton University, Ronald W. Davis, Stanford University School of Medicine, and Dr. David Hogness, Stanford University School of MedicineFor their seminal contributions to the concepts and methods of creating a genetic map in the human, and of positional cloning, leading to the identification of thousands of human disease genes and ushering in the era of human genetics.[7][9] United States
2012Dr. Julian Adams, Infinity Pharmaceuticals, Dr. Kenneth C. Anderson, Dana-Farber Cancer Institute, Dr. Alfred L. Goldberg, Harvard Medical School, and Dr. Paul G. Richardson, Dana-Farber Cancer Institute[10]For the discovery, preclinical and clinical development of bortezomib to FDA approval and front line therapy for the treatment of patients with multiple myeloma.[7] United States
2011Dr. Alain Carpentier, Hôpital Européen Georges-Pompidou, and Dr. Robert Langer, Massachusetts Institute of TechnologyFor their application of bioengineering principles to fundamental improvements in human health.[7][11]

 United States

 France

2009-2010Dr. Howard Green, Harvard Medical SchoolFor development of methodologies for the expansion and differentiation of human keratinocyte stem cells for permanent skin restoration in victims of extensive burns.[7][12] United States
2008Dr. Lloyd Aiello, Joslin Diabetes CenterFor the discovery, characterization and implementation of laser panretinal photocoagulation, which is used to treat proliferative diabetic retinopathy[7] United States
2007Harald zur Hausen and Lutz Gissmann, German Cancer Research CenterFor work leading to the development of a vaccine against human papillomavirus.[13] Germany
2006Dennis Slamon, UCLA; Robert Weinberg, MIT; Michael Shepard, Receptor BioLogix, Inc; and Axel Ullrich, Center for Molecular Medicine,For their work in identifying HER-2/neu as an oncogene and development of the anti-HER-2/neu monoclonal antibody Herceptin for breast cancer therapy.[14] United States  Germany
2005M. Judah Folkman, Harvard Medical School and Boston Children's HospitalFor discovering tumor angiogenesis, and for pioneering work in the development of antiangiogenic therapies for cancer.[7] United States
2004Susan Band Horwitz, Albert Einstein College of MedicineFor her seminal contributions to the understanding of how the antitumor agent Taxol kills cancer cells. United States
2003Sidney Pestka, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, David Goeddel, Tularik, Inc., and Charles Weissmann, Imperial College School of Medicine, London For purification and characterization of interferon alpha; cloning of the human interferon alpha gene and mass production of recombinant interferon alpha for cancer treatment and treatment of hepatitis C.[7] United Kingdom  United States
2002Alfred Sommer, Johns Hopkins University Bloomberg School of Public HealthFor epidemiologic insight into the effects of Vitamin A deficiency, and the resulting reduction in childhood mortality worldwide.[7] United States
2001Eugene Braunwald, Harvard Medical School, and Barry Coller, Rockefeller University School of Medicine.For work in cardiac physiology and pathophysiology, leading to the use of monoclonal antibodies to platelet surface antigens in antithrombotic therapy.[7] United States
2000David Baltimore, California Institute of Technology, Brian Druker, Oregon Health Sciences University, Nicholas Lydon, Amgen, Inc., Alex Matter, Novartis Pharma AG, and Owen Witte, University of California, Los Angeles.For Development of Abl kinase inhibitors for use in the treatment of chronic myelogenous leukemia[7] United States  Switzerland
1999Michael S. Brown and Joseph L. Goldstein, University of Texas Southwestern Medical School, Akira Endo (biochemist), Tokyo Noko UniversityFor Development of HMG CoA reductase inhibitors.[7] United States  Japan
1998K. Frank Austen, Harvard Medical SchoolFor elucidating the role of leukotrienes in asthma.[7] United States
1997Robert C. Gallo, University of Maryland School of Medicine, and Luc Montagnier, Queens College, New YorkFor isolation of the Human Immunodeficiency Virus.[7] United States  France
1996Leo Sachs, Weizmann Institute of Science, and Donald Metcalf, University of MelbourneFor discovery of blood cell growth factors.[7] Israel  Australia
1995John A. Clements, University of California, San FranciscoFor discovery of lung surfactant, and development of synthetic lung surfactant therapy for Infant Respiratory Distress Syndrome.[7] United States
1994J.R. Warren, Royal Perth Hospital, and Barry J. Marshall, University of VirginiaFor linking gastric ulcers to the H. pylori bacterium.[7] Australia
1993Stuart H. Orkin, Harvard Medical School.For genetic and molecular mechanisms of Βeta-Thalassemia and other blood disorders.[7] United States
1992Roscoe O. Brady, National Institutes of HealthFor treatment for Gaucher’s Disease.[7] United States
1991David W. Cushman and Miguel A. Ondetti, Bristol Myers-SquibbFor ACE inhibitor therapy for hypertension and heart failure.[7] United States  Argentina
1990No prize awarded.[7]
1989Yuet Wai Kan, University of California, San FranciscoFor prenatal genetic screening for blood diseases.[7] United States
1988Louis Kunkel, Harvard Medical SchoolFor discovery of the gene associated with a major form of muscular dystrophy.[7] United States
1987Kenneth Murray (biologist), University of EdinburghFor development of a vaccine against Hepatitis B.[7] Scotland

See also

References
  1. Hevesi, Dennis (2007-03-10). "Warren Alpert, 86, Entrepreneur, Is Dead". The New York Times. ISSN 0362-4331. Retrieved 2019-07-16.
  2. "2019 Warren Alpert Prize Recipients Announced | Warren Alpert Foundation Prize". warrenalpert.org. Retrieved 2019-07-16.
  3. "Prize | Warren Alpert Foundation Prize". warrenalpert.org. Retrieved 2019-07-16.
  4. https://warrenalpert.org/prize-recipients
  5. "Alpert Prize Recognizes CRISPR Pioneers". Warren Alpert Foundation. Retrieved 10 March 2016.
  6. "2015 Waren Alpert Foundation Prize recognizes Malaria Breakthroughs". Warren Alpert Foundation. Retrieved 16 August 2015.
  7. "Warren Alpert Foundation Prize announcement". Retrieved 5 July 2013.
  8. Office of Communications and External Relations, Harvard Medical School. "Warren Alpert Foundation Prize Recognizes Leaders in Brain Research". Retrieved 10 June 2014.
  9. Office of Communications and External Relations, Harvard Medical School. "Alpert Foundation Recognizes Genetic Pioneers". Retrieved 5 July 2013.
  10. Conaboy, Chelsea (13 June 2012). "$250,000 Warren Alpert prize goes to researchers for work on blood cancer drug". Boston Globe. Retrieved 13 July 2012.
  11. Office, MIT News. "Langer wins 2011 Warren Alpert Prize". Retrieved 13 July 2012.
  12. Schorr, Melissa (22 April 2012). "Harvard biologist Dr. Howard Green's $250,000 prize". Boston Globe. Retrieved 13 July 2012.
  13. Medical School, Harvard. "HPV, cervical cancer link earns scientists Alpert Prize". Retrieved 13 July 2012.
  14. Medical School, Harvard. "Alpert Winners Trace Path to Life-saving Drug". Retrieved 13 July 2012.
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