Alpha,alpha-trehalose-phosphate synthase (GDP-forming)
In enzymology, an alpha,alpha-trehalose-phosphate synthase (GDP-forming) (EC 2.4.1.36) is an enzyme that catalyzes the chemical reaction
- GDP-glucose + glucose 6-phosphate GDP + alpha,alpha-trehalose 6-phosphate
| alpha,alpha-trehalose-phosphate synthase (GDP-forming) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.36 | ||||||||
| CAS number | 37257-32-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are GDP-glucose and glucose 6-phosphate, whereas its two products are GDP and alpha,alpha'-trehalose 6-phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase. Other names in common use include GDP-glucose-glucose-phosphate glucosyltransferase, guanosine diphosphoglucose-glucose phosphate glucosyltransferase, and trehalose phosphate synthase (GDP-forming).
References
- Elbein AD (February 1967). "Carbohydrate metabolism in Streptomyces hygroscopicus. I. Enzymatic synthesis of trehalose phosphate from guanosine diphosphate D-glucose-14C". The Journal of Biological Chemistry. 242 (3): 403–6. PMID 6022837.
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