HAS2

HAS2
Identifiers
Aliases	HAS2, hyaluronan synthase 2
External IDs	OMIM: 601636 MGI: 107821 HomoloGene: 3892 GeneCards: HAS2
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	121,641,440 bp[1]
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)[2]
End	56,694,539 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • transferase activity, transferring glycosyl groups; • hyaluronan synthase activity; • GO:0001948 protein binding; • identical protein binding;
Cellular component	• cytoplasm; • integral component of membrane; • membrane; • integral component of plasma membrane; • plasma membrane raft;
Biological process	• atrioventricular canal development; • positive regulation of keratinocyte proliferation; • hyaluronan biosynthetic process; • positive regulation of urine volume; • kidney development; • estrous cycle; • positive regulation of cell migration; • cellular response to tumor necrosis factor; • bone morphogenesis; • cellular response to platelet-derived growth factor stimulus; • cellular response to fluid shear stress; • vasculogenesis; • positive regulation of smooth muscle cell migration; • positive regulation of keratinocyte migration; • positive regulation of substrate adhesion-dependent cell spreading; • positive regulation of hyaluronan biosynthetic process; • extracellular matrix assembly; • cellular response to interleukin-1; • positive regulation of cell proliferation; • extracellular polysaccharide biosynthetic process; • hyaluronan metabolic process; • endocardial cushion to mesenchymal transition; • renal water absorption; • positive regulation of monocyte aggregation; • regulation of extracellular matrix assembly;
	Sources:Amigo / QuickGO
Orthologs
	3037
	15117
	ENSG00000170961
	ENSMUSG00000022367
	Q92819
	P70312
	NM_005328
	NM_008216
	NP_005319
	NP_032242
	Wikidata
View/Edit Human	View/Edit Mouse

Hyaluronan synthase 2 is an enzyme that in humans is encoded by the HAS2 gene.[5][6]

Hyaluronan or hyaluronic acid is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. Hyaluronic acid is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded via ABC-Transporter[7] into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. Hyaluronic acid is produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of hyaluronic acid are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of hyaluronic acid with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of hyaluronic acid receptors has been correlated with tumor metastasis. HAS2 is a member of the vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.[6]

References

GRCh38: Ensembl release 89: ENSG00000170961 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022367 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics. 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154.
"Entrez Gene: HAS2 hyaluronan synthase 2".
Schulz,T.; Schumacher,U.; Prehm,P. Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J.Biol.Chem.282,20999-21004

Spicer AP, Nguyen TK (1999). "Mammalian hyaluronan synthases: investigation of functional relationships in vivo". Biochem. Soc. Trans. 27 (2): 109–15. doi:10.1042/bst0270109. PMID 10093717.
Watanabe K, Yamaguchi Y (1996). "Molecular identification of a putative human hyaluronan synthase". J. Biol. Chem. 271 (38): 22945–8. doi:10.1074/jbc.271.38.22945. PMID 8798477.
Simpson MA, Wilson CM, Furcht LT, et al. (2002). "Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells". J. Biol. Chem. 277 (12): 10050–7. doi:10.1074/jbc.M110069200. PMID 11790779.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki K, Yamamoto T, Usui T, et al. (2004). "Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta". Jpn. J. Ophthalmol. 47 (6): 557–64. doi:10.1016/j.jjo.2003.09.001. PMID 14636845.
Sussmann M, Sarbia M, Meyer-Kirchrath J, et al. (2004). "Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins". Circ. Res. 94 (5): 592–600. doi:10.1161/01.RES.0000119169.87429.A0. PMID 14752026.
Monslow J, Williams JD, Guy CA, et al. (2004). "Identification and analysis of the promoter region of the human hyaluronan synthase 2 gene". J. Biol. Chem. 279 (20): 20576–81. doi:10.1074/jbc.M312666200. PMID 14988410.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Morerio C, Rapella A, Rosanda C, et al. (2005). "PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement". Cancer Genet. Cytogenet. 156 (2): 183–4. doi:10.1016/j.cancergencyto.2004.04.017. PMID 15642402.
Ducale AE, Ward SI, Dechert T, Yager DR (2005). "Regulation of hyaluronan synthase-2 expression in human intestinal mesenchymal cells: mechanisms of interleukin-1beta-mediated induction". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (3): G462–70. doi:10.1152/ajpgi.00494.2004. PMID 15677552.
Saavalainen K, Pasonen-Seppänen S, Dunlop TW, et al. (2005). "The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene". J. Biol. Chem. 280 (15): 14636–44. doi:10.1074/jbc.M500206200. PMID 15722343.
Chao H, Spicer AP (2005). "Natural antisense mRNAs to hyaluronan synthase 2 inhibit hyaluronan biosynthesis and cell proliferation". J. Biol. Chem. 280 (30): 27513–22. doi:10.1074/jbc.M411544200. PMID 15843373.
Nishida Y, Knudson W, Knudson CB, Ishiguro N (2005). "Antisense inhibition of hyaluronan synthase-2 in human osteosarcoma cells inhibits hyaluronan retention and tumorigenicity". Exp. Cell Res. 307 (1): 194–203. doi:10.1016/j.yexcr.2005.03.026. PMC 3182490. PMID 15922739.
Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM (2006). "Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells". Biochim. Biophys. Acta. 1760 (6): 890–5. doi:10.1016/j.bbagen.2006.02.002. PMID 16564133.
Monslow J, Williams JD, Fraser DJ, et al. (2006). "Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene". J. Biol. Chem. 281 (26): 18043–50. doi:10.1074/jbc.M510467200. PMID 16603733.
Selbi W, Day AJ, Rugg MS, et al. (2007). "Overexpression of hyaluronan synthase 2 alters hyaluronan distribution and function in proximal tubular epithelial cells". J. Am. Soc. Nephrol. 17 (6): 1553–67. doi:10.1681/ASN.2005080879. PMID 16687630.
Campo GM, Avenoso A, Campo S, et al. (2007). "TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate". Mol. Cell. Biochem. 292 (1–2): 169–78. doi:10.1007/s11010-006-9230-7. PMID 16786194. S2CID 37598580.
Cook AC, Chambers AF, Turley EA, Tuck AB (2006). "Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy". J. Biol. Chem. 281 (34): 24381–9. doi:10.1074/jbc.M602694200. PMID 16807238.
Klewer SE, Yatskievych T, Pogreba K, Stevens MV, Antin PB, Camenisch TD (2006). "Has2 expression in heart forming regions is independent of BMP signaling". Gene Expr Patterns. 6 (5): 462–70. doi:10.1016/j.modgep.2005.11.005. PMID 16458617.
Camenisch TD, Schroeder JA, Bradley J, Klewer SE, McDonald JA (2002). "Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors". Nat. Med. 8 (8): 850–5. doi:10.1038/nm742. PMID 12134143. S2CID 6092884.
Camenisch TD, Spicer AP, Brehm-Gibson T, Biesterfeldt J, Augustine ML, Calabro A Jr, Kubalak S, Klewer SE, McDonald JA (2000). "Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme". J Clin Invest. 106 (3): 349–60. doi:10.1172/JCI10272. PMC 314332. PMID 10930438.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170961 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022367 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9169154-5] Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics. 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154.

[entrez-6] "Entrez Gene: HAS2 hyaluronan synthase 2".

[7] Schulz,T.; Schumacher,U.; Prehm,P. Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J.Biol.Chem.282,20999-21004

HAS2

References

Further reading