ALG9

ALG9
Identifiers
Aliases	ALG9, CDG1L, DIBD1, LOH11CR1J, alpha-1,2-mannosyltransferase, GIKANIS, ALG9 alpha-1,2-mannosyltransferase
External IDs	OMIM: 606941 MGI: 1924753 HomoloGene: 6756 GeneCards: ALG9
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	111,871,581 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	50,843,542 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • mannosyltransferase activity; • dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity; • dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity; • transferase activity, transferring glycosyl groups; • alpha-1,2-mannosyltransferase activity;
Cellular component	• integral component of membrane; • endoplasmic reticulum membrane; • membrane; • endoplasmic reticulum;
Biological process	• protein glycosylation; • dolichol-linked oligosaccharide biosynthetic process; • mannosylation;
	Sources:Amigo / QuickGO
Orthologs
	79796
	102580
	ENSG00000086848
	ENSMUSG00000032059
	Q9H6U8
	Q8VDI9
NM_001077690; NM_001077691; NM_001077692; NM_024740; NM_001352409;
	NM_001352410; NM_001352411; NM_001352412; NM_001352413; NM_001352414; NM_001352415; NM_001352416; NM_001352417; NM_001352418; NM_001352419; NM_001352420; NM_001352421; NM_001352422; NM_001352423
	NM_133981
NP_001071158; NP_001071159; NP_001071160; NP_079016; NP_001339338;
	NP_001339339; NP_001339340; NP_001339341; NP_001339342; NP_001339343; NP_001339344; NP_001339345; NP_001339346; NP_001339347; NP_001339348; NP_001339349; NP_001339350; NP_001339351; NP_001339352
	NP_598742
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-1,2-mannosyltransferase ALG9 is an enzyme that in humans is encoded by the ALG9 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000086848 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032059 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Baysal BE, Willett-Brozick JE, Badner JA, Corona W, Ferrell RE, Nimgaonkar VL, Detera-Wadleigh SD (May 2002). "A mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint that co-segregates with bipolar affective disorder in a small family". Neurogenetics. 4 (1): 43–53. doi:10.1007/s10048-001-0129-x. PMID 12030331. S2CID 39344334.
Frank CG, Grubenmann CE, Eyaid W, Berger EG, Aebi M, Hennet T (May 2004). "Identification and Functional Analysis of a Defect in the Human ALG9 Gene: Definition of Congenital Disorder of Glycosylation Type IL". Am J Hum Genet. 75 (1): 146–50. doi:10.1086/422367. PMC 1181998. PMID 15148656.
"Entrez Gene: ALG9 asparagine-linked glycosylation 9 homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hendricks TJ, Fyodorov DV, Wegman LJ, et al. (2003). "Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior". Neuron. 37 (2): 233–47. doi:10.1016/S0896-6273(02)01167-4. PMID 12546819. S2CID 16152867.
Xu X, Stern DF (2003). "NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors". FASEB J. 17 (13): 1842–8. doi:10.1096/fj.03-0310com. PMID 14519663. S2CID 24870579.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Weinstein M, Schollen E, Matthijs G, et al. (2005). "CDG-IL: an infant with a novel mutation in the ALG9 gene and additional phenotypic features". Am. J. Med. Genet. A. 136 (2): 194–7. doi:10.1002/ajmg.a.30851. PMID 15945070. S2CID 28069253.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
Human ALG9 genome location and ALG9 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000086848 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032059 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12030331-5] Baysal BE, Willett-Brozick JE, Badner JA, Corona W, Ferrell RE, Nimgaonkar VL, Detera-Wadleigh SD (May 2002). "A mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint that co-segregates with bipolar affective disorder in a small family". Neurogenetics. 4 (1): 43–53. doi:10.1007/s10048-001-0129-x. PMID 12030331. S2CID 39344334.

[pmid15148656-6] Frank CG, Grubenmann CE, Eyaid W, Berger EG, Aebi M, Hennet T (May 2004). "Identification and Functional Analysis of a Defect in the Human ALG9 Gene: Definition of Congenital Disorder of Glycosylation Type IL". Am J Hum Genet. 75 (1): 146–50. doi:10.1086/422367. PMC 1181998. PMID 15148656.

[entrez-7] "Entrez Gene: ALG9 asparagine-linked glycosylation 9 homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase)".

ALG9

References

Further reading

External links