FUT2

Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene.[5][6] It affects the secretor status of ABO antigens.[7]

FUT2
Identifiers
AliasesFUT2, B12QTL1, SE, SEC2, Se2, sej, fucosyltransferase 2
External IDsOMIM: 182100 MGI: 109374 HomoloGene: 10325 GeneCards: FUT2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.33Start48,695,971 bp[1]
End48,705,951 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2524

14344

Ensembl

ENSG00000176920

ENSMUSG00000055978

UniProt

Q10981

Q9JL27

RefSeq (mRNA)

NM_001097638
NM_000511

NM_001271993
NM_018876

RefSeq (protein)

NP_000502
NP_001091107

NP_001258922
NP_061364

Location (UCSC)Chr 19: 48.7 – 48.71 MbChr 7: 45.65 – 45.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Approximately 20% of Caucasians are non-secretors due to the G428A (rs601338) and C571T (rs492602?) nonsense mutations in FUT2 and therefore have strong although not absolute protection from the norovirus GII.4.

References

  1. GRCh38: Ensembl release 89: ENSG00000176920 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000055978 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R (Feb 1992). "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Ann Hum Genet. 55 (Pt 3): 225–33. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885. S2CID 30777695.
  6. "Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)".
  7. "Names for H (ISBT 018) Blood Group Alleles" (PDF). www.isbtweb.org. Retrieved 2019-10-13.

Further reading


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