UGT2A2

UGT2A2
Identifiers
Aliases	UGT2A2, UDP glucuronosyltransferase family 2 member A2
External IDs	MGI: 3576095 HomoloGene: 115736 GeneCards: UGT2A2
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	69,639,642 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	87,482,260 bp[2]
Gene ontology
Molecular function	• transferase activity, transferring glycosyl groups; • transferase activity; • glucuronosyltransferase activity; • transferase activity, transferring hexosyl groups; • UDP-glycosyltransferase activity;
Cellular component	• integral component of membrane; • intracellular membrane-bounded organelle; • membrane;
Biological process	• sensory perception of smell; • detection of chemical stimulus; • cellular glucuronidation; • response to stimulus; • metabolism;
	Sources:Amigo / QuickGO
Orthologs
	574537
	552899
	ENSG00000271271
	ENSMUSG00000029268
	Q9Y4X1
	Q6PDD0
	NM_001301233; NM_001105677
	NM_001024148
NP_001099147; NP_001288162; NP_001239203; NP_001239204; NP_001288168;
	NP_006789
	NP_001019319
	Wikidata
View/Edit Human	View/Edit Mouse

'UDP glucuronosyltransferase 2 family, polypeptide A2, also known as UGT2A2, is an enzyme that in humans is encoded by the UGT2A2 gene.[5][6]

Function

The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants.[5]

References

GRCh38: Ensembl release 89: ENSG00000271271 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029268 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: UDP glucuronosyltransferase 2 family, polypeptide A2".
Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, Nebert DW (October 2005). "Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily". Pharmacogenet. Genomics. 15 (10): 677–85. doi:10.1097/01.fpc.0000173483.13689.56. PMID 16141793.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000271271 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029268 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: UDP glucuronosyltransferase 2 family, polypeptide A2".

[pmid16141793-6] Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, Nebert DW (October 2005). "Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily". Pharmacogenet. Genomics. 15 (10): 677–85. doi:10.1097/01.fpc.0000173483.13689.56. PMID 16141793.