Amphinase

Amphinase is a ribonuclease enzyme found in the oocytes of the Northern leopard frog (Rana pipiens). Amphinase is a member of the pancreatic ribonuclease protein superfamily and degrades long RNA substrates.[2] Along with ranpirnase, another leopard frog ribonuclease, amphinase has been studied as a potential cancer therapy due to its unusual mechanism of cytotoxicity tested against tumor cells.[3]

Amphinase
Crystallographic structure of amphinase.[1]
Identifiers
OrganismRana pipiens
Symboln/a
PDB2P7S
UniProtP85073
Other data
EC number3.1.27

References
  1. Singh UP, Ardelt W, Saxena SK, Holloway DE, Vidunas E, Lee HS, Saxena A, Shogen K, Acharya KR (August 2007). "Enzymatic and structural characterisation of amphinase, a novel cytotoxic ribonuclease from Rana pipiens oocytes". Journal of Molecular Biology. 371 (1): 93–111. doi:10.1016/j.jmb.2007.04.071. PMID 17560606.
  2. Singh UP, Ardelt W, Saxena SK, Holloway DE, Vidunas E, Lee HS, Saxena A, Shogen K, Acharya KR (August 2007). "Enzymatic and structural characterisation of amphinase, a novel cytotoxic ribonuclease from Rana pipiens oocytes". Journal of Molecular Biology. 371 (1): 93–111. doi:10.1016/j.jmb.2007.04.071. PMID 17560606.
  3. Ardelt W, Shogen K, Darzynkiewicz Z (June 2008). "Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes". Current Pharmaceutical Biotechnology. 9 (3): 215–25. doi:10.2174/138920108784567245. PMC 2586917. PMID 18673287.


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