Atypical antidepressant

An atypical antidepressant is any antidepressant medication that acts in an manner that is different from that of most other antidepressants. Atypical antidepressants include agomelatine, bupropion, mianserin, mirtazapine, nefazodone, opipramol, tianeptine, and trazodone.[1][2][3] The agents vilazodone and vortioxetine are partly atypical. Typical antidepressants include the SSRIs, SNRIs, TCAs, and MAOIs, which act mainly by increasing the levels of the monoamine neurotransmitters serotonin and/or norepinephrine.[1][2][3] Among TCAs, trimipramine is an atypical agent in that it appears not to do this.[3]

Esketamine (JNJ-54135419) and buprenorphine/samidorphan (ALKS-5461) are antidepressants with novel mechanisms of action which are under development and are considered atypical antidepressants.[4] They act faster than available antidepressants.[4]

See also

References
  1. Feighner JP (1999). "Mechanism of action of antidepressant medications". J Clin Psychiatry. 60 Suppl 4: 4–11, discussion 12–3. PMID 10086478.
  2. Stahl SM (1998). "Basic psychopharmacology of antidepressants, part 1: Antidepressants have seven distinct mechanisms of action". J Clin Psychiatry. 59 Suppl 4: 5–14. PMID 9554316.
  3. Frazer A (1997). "Pharmacology of antidepressants". J Clin Psychopharmacol. 17 Suppl 1: 2S–18S. doi:10.1097/00004714-199704001-00002. PMID 9090573.
  4. Garay RP, Zarate CA, Charpeaud T, Citrome L, Correll CU, Hameg A, Llorca PM (2017). "Investigational drugs in recent clinical trials for treatment-resistant depression". Expert Rev Neurother. 17 (6): 593–609. doi:10.1080/14737175.2017.1283217. PMC 5418088. PMID 28092469.


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