B-1,4-mannosyl-glycoprotein 4-b-N-acetylglucosaminyltransferase

Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.144, N-acetylglucosaminyltransferase III, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III, beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, GnTIII) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase.[1][2] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Identifiers
EC number2.4.1.144
CAS number83744-93-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.

References
  1. Narasimhan S (September 1982). "Control of glycoprotein synthesis. UDP-GlcNAc:glycopeptide beta 4-N-acetylglucosaminyltransferase III, an enzyme in hen oviduct which adds GlcNAc in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-glycosyl oligosaccharides". The Journal of Biological Chemistry. 257 (17): 10235–42. PMID 6213618.
  2. Schachter H, Narasimhan S, Gleeson P, Vella G (1983). "Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type". Methods in Enzymology. 98: 98–134. doi:10.1016/0076-6879(83)98143-0. PMID 6366476.
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