Bone morphogenetic protein 5

Bone morphogenetic protein 5 is a protein that in humans is encoded by the BMP5 gene.[5][6][7]

BMP5
Identifiers
AliasesBMP5, entrez:653, bone morphogenetic protein 5
External IDsOMIM: 112265 MGI: 88181 HomoloGene: 22412 GeneCards: BMP5
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p12.1Start55,753,653 bp[1]
End55,875,590 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

653

12160

Ensembl

ENSG00000112175

ENSMUSG00000032179

UniProt

P22003

P49003

RefSeq (mRNA)

NM_021073
NM_001329754
NM_001329756

NM_007555

RefSeq (protein)

NP_001316683
NP_001316685
NP_066551
NP_066551.1

NP_031581

Location (UCSC)Chr 6: 55.75 – 55.88 MbChr 9: 75.78 – 75.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP5 may play a role in certain cancers. Like other BMP's BMP5 is inhibited by chordin and noggin. It is expressed in the trabecular meshwork and optic nerve head and may have a role in the development and normal function. It is also expressed in the lung and liver.

This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000112175 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032179 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Nov 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.
  6. Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ (Mar 2003). "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons". BMC Neuroscience. 2: 12. doi:10.1186/1471-2202-2-12. PMC 56999. PMID 11580864.
  7. "Entrez Gene: BMP5 bone morphogenetic protein 5".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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