Mothers against decapentaplegic homolog 5

Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.[5]

SMAD5
Identifiers
AliasesSMAD5, DWFC, JV5-1, MADH5, SMAD family member 5
External IDsOMIM: 603110 MGI: 1328787 HomoloGene: 4313 GeneCards: SMAD5
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q31.1Start136,132,845 bp[1]
End136,188,747 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

4090

17129

Ensembl

ENSG00000113658

ENSMUSG00000021540

UniProt

Q99717

P97454

RefSeq (mRNA)

NM_005903
NM_001001419
NM_001001420

NM_001164041
NM_001164042
NM_008541

RefSeq (protein)

NP_001001419
NP_001001420
NP_005894

NP_001157513
NP_001157514
NP_032567

Location (UCSC)Chr 5: 136.13 – 136.19 MbChr 13: 56.7 – 56.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic", based on a tradition of such unusual naming within the gene research community.[6] It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.

References

  1. GRCh38: Ensembl release 89: ENSG00000113658 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021540 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135. S2CID 10124489.
  6. "Sonic Hedgehog, DICER, and the Problem With Naming Genes", Sep 26, 2014, Michael White. psmag.com


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