Mothers against decapentaplegic homolog 5

Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene.[5]

SMAD5
Identifiers
Aliases	SMAD5, DWFC, JV5-1, MADH5, SMAD family member 5
External IDs	OMIM: 603110 MGI: 1328787 HomoloGene: 4313 GeneCards: SMAD5
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 136,132,845 bp[1] End 136,188,747 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 30.12 cM Start 56,703,010 bp[2] End 56,742,377 bp[2]
Gene ontology Molecular function • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • metal ion binding • GO:0001948 protein binding • ubiquitin protein ligase binding • DEAD/H-box RNA helicase binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • SMAD protein complex • transcription regulator complex • intracellular • nucleoplasm • cell nucleus • cytoplasm • cytosol • macromolecular complex Biological process • germ cell development • ureteric bud development • cardiac muscle contraction • regulation of transcription, DNA-templated • SMAD protein signal transduction • embryonic pattern specification • ossification • cellular response to organic cyclic compound • cellular response to BMP stimulus • BMP signaling pathway • transcription, DNA-templated • positive regulation of transcription, DNA-templated • Mullerian duct regression • protein phosphorylation • cartilage development • positive regulation of osteoblast differentiation • erythrocyte differentiation • bone development • transforming growth factor beta receptor signaling pathway • signal transduction • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • positive regulation of transcription from RNA polymerase II promoter • osteoblast fate commitment • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4090	17129
Ensembl	ENSG00000113658	ENSMUSG00000021540
UniProt	Q99717	P97454
RefSeq (mRNA)	NM_005903 NM_001001419 NM_001001420	NM_001164041 NM_001164042 NM_008541
RefSeq (protein)	NP_001001419 NP_001001420 NP_005894	NP_001157513 NP_001157514 NP_032567
Location (UCSC)	Chr 5: 136.13 – 136.19 Mb	Chr 13: 56.7 – 56.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic", based on a tradition of such unusual naming within the gene research community.[6] It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.