Disufenton sodium

Disufenton sodium (NXY-059, Cerovive) is the disulfonyl derivative of the neuroprotective spin trap phenylbutylnitrone or "PBN". It was under development at the drug company AstraZeneca. A 2005 phase-3 clinical trial[1][2] called "SAINT-1" reported some efficacy in the acute treatment of ischemia injury due to stroke. However, a 2006 attempt to repeat this trial indicated no significant activity. After ruling out other causes, the authors tentatively attributed the positive results in the first trial to "chance".[1] AstraZeneca then terminated the development programme.[3] PBN and its derivatives hydrolyze and oxidize in vitro to form respectively MNP-OH (AKA, NtBHA) and its parent spin-trap MNP.

Disufenton sodium

Clinical data
ATC code	none
Identifiers
IUPAC name Disodium 4-[(Z)-(tert-butyl-oxidoazaniumylidene)methyl]benzene-1,3-disulfonate
CAS Number	168021-79-2 Y
PubChem CID	6440181
ChemSpider	28530805 N
UNII	7M1J3HN9VO
KEGG	D03875 Y
ChEMBL	ChEMBL1627056 N
Chemical and physical data
Formula	C11H13NNa2O7S2
Molar mass	381.32 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)(C)[N+]([O-])=Cc1ccc(cc1S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+]
InChI InChI=1S/C11H15NO7S2.2Na/c1-11(2,3)12(13)7-8-4-5-9(20(14,15)16)6-10(8)21(17,18)19;;/h4-7H,1-3H3,(H,14,15,16)(H,17,18,19);;/q;2*+1/p-2 N Key:XLZOVRYBVCMCGL-UHFFFAOYSA-L N
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