GUCY2F

Retinal guanylyl cyclase 2 also known as guanylate cyclase F (GUCY2F) is a protein that in humans is encoded by the GUCY2F gene.[5]

GUCY2F
Identifiers
AliasesGUCY2F, CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2, guanylate cyclase 2F, retinal
External IDsOMIM: 300041 MGI: 105119 HomoloGene: 37491 GeneCards: GUCY2F
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq22.3-q23Start109,372,906 bp[1]
End109,482,086 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

2986

245650

Ensembl

ENSG00000101890

ENSMUSG00000042282

UniProt

P51841

Q5SDA5

RefSeq (mRNA)

NM_001522

NM_001007576

RefSeq (protein)

NP_001513

NP_001007577

Location (UCSC)Chr X: 109.37 – 109.48 MbChr X: 142.08 – 142.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein.[5]

Clinical significance

Defects in this gene may be a cause of X-linked retinitis pigmentosa.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000101890 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000042282 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Guanylate cyclase 2F, retinal".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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