Glucosylceramide beta-1,4-galactosyltransferase

Glucosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.274, lactosylceramide synthase, uridine diphosphate-galactose:glucosyl ceramide beta 1-4 galactosyltransferase, UDP-Gal:glucosylceramide beta1->4galactosyltransferase, GalT-2, UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase) is an enzyme with systematic name UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Glucosylceramide beta-1,4-galactosyltransferase
Identifiers
EC number2.4.1.274
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Involved in the synthesis of several different major classes of glycosphingolipids.

References
  1. Chatterjee S, Castiglione E (January 1987). "UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes". Biochimica et Biophysica Acta. 923 (1): 136–42. doi:10.1016/0304-4165(87)90136-X. PMID 3099851.
  2. Trinchera M, Fiorilli A, Ghidoni R (March 1991). "Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide beta 1----4galactosyltransferase". Biochemistry. 30 (10): 2719–24. doi:10.1021/bi00224a021. PMID 1900430.
  3. Chatterjee S, Ghosh N, Khurana S (April 1992). "Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney". The Journal of Biological Chemistry. 267 (10): 7148–53. PMID 1551920.
  4. Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N (May 1998). "Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain". The Journal of Biological Chemistry. 273 (22): 13570–7. doi:10.1074/jbc.273.22.13570. PMID 9593693.
  5. Takizawa M, Nomura T, Wakisaka E, Yoshizuka N, Aoki J, Arai H, Inoue K, Hattori M, Matsuo N (May 1999). "cDNA cloning and expression of human lactosylceramide synthase". Biochimica et Biophysica Acta. 1438 (2): 301–4. doi:10.1016/S1388-1981(99)00051-7. PMID 10320813.
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