Peptide-O-fucosyltransferase
In enzymology, a peptide-O-fucosyltransferase (EC 2.4.1.221) is an enzyme that catalyzes the chemical reaction in which an alpha-L-fucosylpyranoside residue is transferred from GDP-beta-L-fucose to the sidechain oxygen atom of a serine or threonine residue in a protein.
| peptide-O-fucosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.221 | ||||||||
| CAS number | 9033-08-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase. Other names in common use include GDP-L-fucose:polypeptide fucosyltransferase, GDP-fucose protein O-fucosyltransferase, and GDP-fucose:polypeptide fucosyltransferase.
References
- Wang Y, Spellman MW (1998). "Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells". J. Biol. Chem. 273 (14): 8112–8. doi:10.1074/jbc.273.14.8112. PMID 9525914.
- Haltiwanger RS; Shao, L; Shi, S; Harris, RJ; Spellman, MW; Stanley, P; Haltiwanger, RS (2001). "Modification of epidermal growth factor-like repeats with O-fucose Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase". J. Biol. Chem. 276 (43): 40338–45. doi:10.1074/jbc.M107849200. PMID 11524432.
- Wang Y, Lee GF, Kelley RF, Spellman MW (1996). "Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains". Glycobiology. 6 (8): 837–42. doi:10.1093/glycob/6.8.837. PMID 9023546.
- Peter-Katalinic J; Huwiler, KG; Macek, B; Hess, D; Lawler, J; Mosher, DF; Peter-Katalinic, J (2001). "C-mannosylation and O-fucosylation of the thrombospondin type 1 module". J. Biol. Chem. 276 (9): 6485–98. doi:10.1074/jbc.M008073200. PMID 11067851.
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