Polypeptide N-acetylgalactosaminyltransferase

In enzymology, a polypeptide N-acetylgalactosaminyltransferase (EC 2.4.1.41) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-galactosamine + polypeptide UDP + N-acetyl-D-galactosaminyl-polypeptide
polypeptide N-acetylgalactosaminyltransferase
Identifiers
EC number2.4.1.41
CAS number9075-15-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-galactosamine and polypeptide, whereas its two products are UDP and N-acetyl-D-galactosaminyl-polypeptide.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1. It has 2 cofactors: manganese, and calcium.

Nomenclature

The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase. Other names in common use include:

  • protein-UDP acetylgalactosaminyltransferase,
  • UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase,
  • UDP-N-acetylgalactosamine:kappa-casein polypeptide,
  • N-acetylgalactosaminyltransferase,
  • uridine diphosphoacetylgalactosamine-glycoprotein,
  • acetylgalactosaminyltransferase,
  • glycoprotein acetylgalactosaminyltransferase,
  • polypeptide-N-acetylgalactosamine transferase,
  • UDP-acetylgalactosamine-glycoprotein,
  • acetylgalactosaminyltransferase,
  • UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase,
  • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase,
  • UDP-N-acetyl-alpha-D-galactosamine:polypeptide,
  • N-acetylgalactosaminyltransferase,
  • UDP-N-acetylgalactosamine-glycoprotein,
  • N-acetylgalactosaminyltransferase,
  • UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase,
  • UDP-N-acetylgalactosamine:polypeptide,
  • N-acetylgalactosaminyltransferase, and
  • UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase.

References
    • Sugiura M, Kawasaki T, Yamashina I (1982). "Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66". J. Biol. Chem. 257 (16): 9501–7. PMID 6809738.
    • Takeuchi M, Yoshikawa M, Sasaki R, Chiba H (1985). "Purification and characterization of UDP-N-acetylgalactosamine-kappa-casein polypeptide N-acetylgalactosaminyltransferase from mammary-gland of lactating cow". Agric. Biol. Chem. 49 (4): 1059–1069. doi:10.1271/bbb1961.49.1059.


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