3-hydroxyanthranilate oxidase
In enzymology, a 3-hydroxyanthranilate oxidase (EC 1.10.3.5) (also called 3-HAO) is an enzyme that catalyzes the chemical reaction:[1]
- 3-hydroxyanthranilate + O2 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2
| 3-hydroxyanthranilate oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.10.3.5 | ||||||||
| CAS number | 37256-53-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3-hydroxyanthranilate and O2, whereas its two products are 6-imino-5-oxocyclohexa-1,3-dienecarboxylate and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on diphenols and related substances as donor with oxygen as acceptor. The systematic name of this enzyme class is 3-hydroxyanthranilate:oxygen oxidoreductase. This enzyme is also called 3-hydroxyanthranilic acid oxidase.
References
- Vécsei, L; Szalárdy, L; Fülöp, F; Toldi, J (January 2013). "Kynurenines in the CNS: recent advances and new questions". Nature Reviews. Drug Discovery. 12 (1): 64–82. doi:10.1038/nrd3793. PMID 23237916.
- Morgan LR Jr, Weimorts DM, Aubert CC (1965). "Oxidation Of 3-hydroxyanthranilic acid by a soluble liver fraction from poikilothermic vertebrates". Biochim. Biophys. Acta. 100: 393–402. doi:10.1016/0304-4165(65)90008-5. PMID 14347936.
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