Blocking (statistics)

• Male and Female: An experiment is designed to test a new drug on patients. There are two levels of the treatment, drug, and placebo, administered to male and female patients in a double blind trial. The sex of the patient is a blocking factor accounting for treatment variability between males and females. This reduces sources of variability and thus leads to greater precision.
• Elevation: An experiment is designed to test the effects of a new pesticide on a specific patch of grass. The grass area contains a major elevation change and thus consists of two distinct regions - 'high elevation' and 'low elevation'. A treatment group (the new pesticide) and a placebo group are applied to both the high elevation and low elevation areas of grass. In this instance the researcher is blocking the elevation factor which may account for variability in the pesticide's application.
• Intervention: Suppose a process is invented that intends to make the soles of shoes last longer, and a plan is formed to conduct a field trial. Given a group of n volunteers, one possible design would be to give n/2 of them shoes with the new soles and n/2 of them shoes with the ordinary soles, randomizing the assignment of the two kinds of soles. This type of experiment is a completely randomized design. Both groups are then asked to use their shoes for a period of time, and then measure the degree of wear of the soles. This is a workable experimental design, but purely from the point of view of statistical accuracy (ignoring any other factors), a better design would be to give each person one regular sole and one new sole, randomly assigning the two types to the left and right shoe of each volunteer. Such a design is called a "randomized complete block design." This design will be more sensitive than the first, because each person is acting as his/her own control and thus the control group is more closely matched to the treatment group.

When we can control nuisance factors, an important technique known as blocking can be used to reduce or eliminate the contribution to experimental error contributed by nuisance factors. The basic concept is to create homogeneous blocks in which the nuisance factors are held constant and the factor of interest is allowed to vary. Within blocks, it is possible to assess the effect of different levels of the factor of interest without having to worry about variations due to changes of the block factors, which are accounted for in the analysis.

A nuisance factor is used as a blocking factor if every level of the primary factor occurs the same number of times with each level of the nuisance factor. The analysis of the experiment will focus on the effect of varying levels of the primary factor within each block of the experiment.

The general rule is:

“Block what you can; randomize what you cannot.”

Blocking is used to remove the effects of a few of the most important nuisance variables. Randomization is then used to reduce the contaminating effects of the remaining nuisance variables. For important nuisance variables, blocking will yield higher significance in the variables of interest than randomizing.

One useful way to look at a randomized block experiment is to consider it as a collection of completely randomized experiments, each run within one of the blocks of the total experiment.

Randomized Block Designs (RBD)

Name of Design	Number of Factors k	Number of Runs n
2-factor RBD	2	L1 * L2
3-factor RBD	3	L1 * L2 * L3
4-factor RBD	4	L1 * L2 * L3 * L4
${\displaystyle \vdots }$	${\displaystyle \vdots }$	${\displaystyle \vdots }$
k-factor RBD	k	L1 * L2 * ${\displaystyle \cdots }$ * Lk

with

L₁ = number of levels (settings) of factor 1

L₂ = number of levels (settings) of factor 2

L₃ = number of levels (settings) of factor 3

L₄ = number of levels (settings) of factor 4

${\displaystyle \vdots }$

L_k = number of levels (settings) of factor k

Suppose engineers at a semiconductor manufacturing facility want to test whether different wafer implant material dosages have a significant effect on resistivity measurements after a diffusion process taking place in a furnace. They have four different dosages they want to try and enough experimental wafers from the same lot to run three wafers at each of the dosages.

The nuisance factor they are concerned with is "furnace run" since it is known that each furnace run differs from the last and impacts many process parameters.

An ideal way to run this experiment would be to run all the 4x3=12 wafers in the same furnace run. That would eliminate the nuisance furnace factor completely. However, regular production wafers have furnace priority, and only a few experimental wafers are allowed into any furnace run at the same time.

A non-blocked way to run this experiment would be to run each of the twelve experimental wafers, in random order, one per furnace run. That would increase the experimental error of each resistivity measurement by the run-to-run furnace variability and make it more difficult to study the effects of the different dosages. The blocked way to run this experiment, assuming you can convince manufacturing to let you put four experimental wafers in a furnace run, would be to put four wafers with different dosages in each of three furnace runs. The only randomization would be choosing which of the three wafers with dosage 1 would go into furnace run 1, and similarly for the wafers with dosages 2, 3 and 4.

Let X₁ be dosage "level" and X₂ be the blocking factor furnace run. Then the experiment can be described as follows:

k = 2 factors (1 primary factor X₁ and 1 blocking factor X₂)

L₁ = 4 levels of factor X₁

L₂ = 3 levels of factor X₂

n = 1 replication per cell

N = L₁ * L₂ = 4 * 3 = 12 runs

Before randomization, the design trials look like:

An alternate way of summarizing the design trials would be to use a 4x3 matrix whose 4 rows are the levels of the treatment X₁ and whose columns are the 3 levels of the blocking variable X₂. The cells in the matrix have indices that match the X₁, X₂ combinations above.

By extension, note that the trials for any K-factor randomized block design are simply the cell indices of a k dimensional matrix.

The model for a randomized block design with one nuisance variable is

${\displaystyle Y_{ij}=\mu +T_{i}+B_{j}+\mathrm {random\ error} }$

where

Y_ij is any observation for which X₁ = i and X₂ = j

X₁ is the primary factor

X₂ is the blocking factor

μ is the general location parameter (i.e., the mean)

T_i is the effect for being in treatment i (of factor X₁)

B_j is the effect for being in block j (of factor X₂)

Estimate for μ : ${\displaystyle {\overline {Y}}}$ = the average of all the data

Estimate for T_i : ${\displaystyle {\overline {Y}}_{i\cdot }-{\overline {Y}}}$ with ${\displaystyle {\overline {Y}}_{i\cdot }}$ = average of all Y for which X₁ = i.

Estimate for B_j : ${\displaystyle {\overline {Y}}_{\cdot j}-{\overline {Y}}}$ with ${\displaystyle {\overline {Y}}_{\cdot j}}$ = average of all Y for which X₂ = j.

• Generalized randomized block designs (GRBD) allow tests of block-treatment interaction, and has exactly one blocking factor like the RCBD.
• Latin squares (and other row-column designs) have two blocking factors that are believed to have no interaction.
• Latin hypercube sampling
• Graeco-Latin squares
• Hyper-Graeco-Latin square designs