Excitatory amino acid transporter 4

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.[5][6]

SLC1A6
Identifiers
AliasesSLC1A6, EAAT4, solute carrier family 1 member 6
External IDsOMIM: 600637 MGI: 1096331 HomoloGene: 21055 GeneCards: SLC1A6
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.12Start14,950,034 bp[1]
End15,022,990 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

6511

20513

Ensembl

ENSG00000105143

ENSMUSG00000005357

UniProt

P48664

O35544

RefSeq (mRNA)

NM_001272087
NM_001272088
NM_005071

NM_009200

RefSeq (protein)

NP_001259016
NP_001259017
NP_005062

NP_033226

Location (UCSC)Chr 19: 14.95 – 15.02 MbChr 10: 78.78 – 78.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000105143 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000005357 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)".
  6. Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (June 1995). "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature. 375 (6532): 599–603. doi:10.1038/375599a0. PMID 7791878. S2CID 4334983.

Further reading


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