List of largest selling pharmaceutical products

Best selling pharmaceuticals of U.S. Market

The top 5 best selling pharmaceuticals 2015-2019. Sales in billion USD.[1]

Rank Drug Main indication Trade name 2015 2016 2017 2018 2019
1 adalimumab rheumatoid arthritis Humira 10.1 13.5 16.3 18.4 21.4
2 apixaban anticoagulant Eliquis 1.6 3.0 4.6 7.1 9.9
3 etanercept rheumatoid arthritis Enbrel 7.2 7.6 7.9 8.0 8.1
4 ustekinumab psoriasis Stelara 2.0 2.6 3.7 5.0 6.6
5 pembrolizumab oncology Keytruda 0.4 0.7 2.2 4.3 6.5

Best selling pharmaceuticals of 2017/18

The top 16 best selling pharmaceuticals of 2017/18.[2]

Rank Drug Main indication Trade name 2018 sales (million USD) 2017 sales (million USD)
1 adalimumab rheumatoid arthritis Humira 19 936 18427
3 apixaban anticoagulant Eliquis 9872 7395
4 lenalidomide multiple myeloma Revlimid 9685 8187
5 nivolumab oncology Opdivo 7570 5763
6 pembrolizumab oncology Keytruda 7171 3809
7 etanercept rheumatoid arthritis Enbrel 7126 7885
8 trastuzumab breast cancer Herceptin 6981 7013
9 bevacizumab colon cancer Avastin 6847 6686
10 rituximab non-Hodgkin's lymphoma Rituxan,

MabThera

6750 7298
11 rivaroxaban anticoagulant Xarelto 6589 6234
12 aflibercept Eylea 6551 5830
13 infliximab Remicade 5908 7152
14 Pneumococcal conjugate vaccine Prevnar 13

Prevenar 13

5802 5601
15 ustekinumab Stelara 5156 4011
16 pregabalin epilepsy Lyrica 4970 5065

Largest selling pharmaceutical products of 2015

Drugs with sales above $5 billion in 2015 included:[3]

Rank Drug Trade name Type Main indications Company Sales (USD millions/year) ∆ vs 2014
1 Adalimumab Humira Biologic Rheumatoid arthritis AbbVie Inc. 14,012 1,469
2 Ledipasvir/sofosbuvir Harvoni Small molecule Hepatitis C Gilead Sciences 13,864 11,737
3 Etanercept Enbrel Biologic Rheumatoid arthritis Amgen

Pfizer

8,697 4,009
4 Infliximab Remicade Biologic Crohn's Disease
Rheumatoid Arthritis
Johnson & Johnson 8,355 1,487
5 Rituximab Mabthera

Rituxan

Biologic Lymphoma

Leukemia

Autoimmune disorders

Roche 7,115 1,456
6 Insulin glargine Lantus Biologic Diabetes mellitus Sanofi 7,029 51
7 Bevacizumab Avastin Biologic Metastatic cancers Roche 6,751 270
8 Trastuzumab Herceptin Biologic Breast cancer Roche 6,603 265
9 Lenalidomide Revlimid Small molecule Multiple myeloma

Myelodysplastic syndromes

Celgene 5,801 821
10 Sofosbuvir Sovaldi Small molecule Hepatitis C Gilead Sciences 5,276 (5,007)
11 Fluticasone propionate/salmeterol Seretide

Advair

Small molecule Asthma

Chronic obstructive pulmonary disease

GlaxoSmithKline 5,227 (778)
12 Rosuvastatin Crestor Small molecule Cardiovascular diseases AstraZeneca 5,017 (495)

Best selling pharmaceuticals of 2013

For the fourth quarter of 2013, the largest selling drugs were:[4]

RankBrand Name(s)Generic NameSales Q1 2014 Sales ($000)Change from Q4 2013Company(ies)Disease/Medical UseFirst Approval DatePatent Expiration Date[5][6]
1AbilifyAripiprazole1,602,3292.23%GenericPsychosis; depressionNov-20022014-Oct
2HumiraAdalimumab1,561,8613.86%AbbVieCrohn's disease; Rheumatoid arthritisDec-20022016-Dec
3NexiumEsomeprazole1,536,4350.74%GenericGastrointestinal disordersMar-20002014-May
4CrestorRosuvastatin1,333,5024.53%AstraZeneca, ShionogiCholesterolNov-20022016-Jul
5EnbrelEtanercept1,189,8441.46%AmgenRheumatoid arthritisNov-19982012-Oct
6Advair Diskus, SeretideFluticasone/salmeterol1,147,3302.65%GlaxoSmithKlineAsthmaAug-20002012-Mar
8RemicadeInfliximab994,020-2.71%Centocor Ortho Biotech, Inc., Mitsubishi Tanabe PharmaCrohn's disease; rheumatoid arthritisAug-1998n/a
9Lantus SolostarInsulin glargine939,6919.39%Sanofi-AventisDiabetes mellitus type 1 and 2Apr-20002011-Dec
10NeulastaPegfilgrastim854,508-4.90%AmgenNeutropeniaJan-2002Mon-20XX
11CopaxoneGlatiramer851,351-4.69%GenericMultiple sclerosisDec-1996Nov-2014
12Rituxan, MabTheraRituximab746,766-0.16%Biogen Idec, Chugai Pharmaceutical, Genentech/RocheNon-Hodgkin’s lymphoma; rheumatoid arthritisNov-1997Mon-20XX
13SpirivaTiotropium bromide726,0573.39%Boehringer IngelheimChronic obstructive pulmonary diseaseApr-20022018-Jul
14JanuviaSitagliptin700,9413.63%Merck & Co., Inc.Diabetes mellitus type 2Dec-19962017-Nov
15LantusInsulin glargine685,4615.84%Sanofi-AventisDiabetes mellitus type 1 and 2Apr-2000Dec-2011
16AtriplaEmtricitabine/tenofovir/efavirenz679,4180.36%Gilead Sciences, Inc.HIV infectionDec-1996Mar-2015
17CymbaltaDuloxetine664,186-23.06%GenericDepression; anxiety disordersAug-2004Dec-2013
18AvastinBevacizumab650,208-1.25%Genentech/RocheCancerFeb-2004Mon-20XX
19LyricaPregabalin624,7742.82%PfizerNeuropathic painJul-2004Jul-2019
20OxyContinOxycodone585,482-2.91%GenericPainDec-1996Mon-20XX
21CelebrexCelecoxib580,3325.23%GenericOsteoarthritis; rheumatoid arthritisDec-1998May-2014
22EpogenEpoetin alfa503,493-2.08%AmgenAnemiaJun-1989Mon-20XX
23TruvadaTenofovir/emtricitabine542,8460.03%Gilead SciencesHIV infectionAug-2004Mon-20XX
24DiovanValsartan533,924-2.80%GenericHypertensionDec-1996Sep-2012
25LevemirInsulin detemir424,1869.34%Novo NordiskDiabetes mellitus type 1 and 2Dec-1990Mon-20XX
26Gleevec, GlivecImatinib498,1497.22%NovartisLeukemiaMay-2001Jan-2015
27HerceptinTrastuzumab473,6321.53%Chugai Pharmaceutical, Genentech/RocheBreast cancerSep-1998Mon-20XX
28VyvanseLisdexamfetamine447,1889.39%ShireAttention deficit hyperactivity disorderDec-1990Mon-20XX
29LucentisRanibizumab460,621-0.84%GenentechMacular degenerationDec-1990Mon-20XX
30ZetiaEzetimibe444,7314.04%Merck & Co., Schering-PloughCholesterolOct-20022017-Oct
31CombiventIpratropium bromide/salbutamol391,40420.28%Boehringer IngelheimChronic obstructive pulmonary diseaseOct-1996Mon-20XX
32SymbicortBudesonide/formoterol407,6469.63%AstraZenecaAsthmaAug-2000Mon-20XX
33NamendaMemantine434,766-6.00%GenericAlzheimer's diseaseOct-2003Apr-2014 [9]
34NovoLog FlexPenInsulin aspart364,8707.84%Novo NordiskDiabetes mellitus type 1 and 2Oct-1996Mon-20XX
35XareltoRivaroxaban321,46218.72%BayerOral anticoagulantDec-1996Sep-2012
36NovoLogInsulin aspart344,2353.86%Novo NordiskDiabetes mellitus type 1 and 2Oct-1996Mon-20XX
37HumalogInsulin lispro304,8666.15%Eli Lilly and CompanyDiabetes mellitus type 1 and 2Apr-1996Mon-20XX
38SuboxoneBuprenorphine321,892-2.11%Reckitt Benckiser Pharmaceuticals Inc.Pain; opioid addictionAug-2000Mon-20XX
40ViagraSildenafil300,4633.26%PfizerErectile dysfunctionMar-1998Mar-2012
41Seroquel XRQuetiapine291,4942.22%GenericPsychosis; depressionSep-1997Mar-2012
33IncivoTelaprevir370,8990.00%Johnson & JohnsonHepatitis CDec-1990Mon-20XX
35AndroGelTestosterone gel351,7375.47%GenericLow testosterone levelsOct-2002Oct-2016
37EnoxaparinEnoxaparin341,1846.55%GenericDeep-vein thrombosisMar-19932012-Aug
38RitalinMethylphenidate327,3462.26%GenericAttention deficit hyperactivity disorderAug-2000Mon-20XX
41ProAir HFASalbutamol306,46110.87%Teva PharmaceuticalsAsthma; chronic obstructive pulmonary diseaseOct-1996Mon-20XX
43AlimtaPemetrexed302,7286.00%Eli Lilly and CompanyCancerFeb-2004Mon-20XX
44VictozaLiraglutide301,4149.59%Novo NordiskDiabetes mellitus type 2May-1909Mon-20XX
47SynagisPalivizumab289,7040.00%MedImmuneRSV infectionFeb-1998Aug-2012
48AvonexInterferon beta 1a281,554-1.43%Biogen IdecMultiple sclerosisMay-1996Mon-20XX
49RenvelaSevelamer280,91721.44%GenericHyperphosphatemiaApr-2002Apr-2016 [10]
50RebifInterferon beta 1a280,548-6.27%SeronoMultiple sclerosisFeb-1998Mon-20XX
51CialisTadalafil280,5184.58%Eli Lilly and Company, Lilly IcosErectile dysfunctionNov-20022017-Nov
52Gilenyafingolimod272,7014.05%Novartis CorporationMultiple sclerosisFeb-20002007-Jan
53NasonexMometasone272,3455.67%Schering-PloughAllergic rhinitisOct-19972018-Oct
54StelaraUstekinumab270,59812.47%Johnson & JohnsonPsoriasis; psoriatic arthritisApr-2000Mon-20XX
55RestasisCiclosporin ophthalmic emulsion268,4636.30%Allergan, Inc, Lilly IcosDry eye syndromeNov-2002Mon-20XX
56BudesonideBudesonide268,20126.81%GenericAsthmaAug-2000Mon-20XX
57Acetaminophen/hydrocodoneAcetaminophen/hydrocodone264,8146.67%GenericPainAug-2000Mon-20XX
58Flovent HFAFluticasone propionate263,07213.97%GlaxoSmithKlineAsthmaMar-1996Mon-20XX
59LovazaOmega-3 fatty acid ethyl esters258,1772.90%GlaxoSmithKlineCholesterolJun-2001Mon-20XX
60PrezistaDarunavir251,3723.54%Johnson & JohnsonHIV infectionJun-2006Mon-20XX
61IsentressRaltegravir248,9240.72%Merck & Co., Inc.HIV InfectionDec-1998Mon-20XX
62JanumetSitagliptin/metformin247,1504.65%Merck & Co., Inc.Diabetes mellitus type 2Dec-1998Mon-20XX
63Procrit, EprexEpoetin alfa241,535-10.09%Johnson & JohnsonAnemiaDec-1990Mon-20XX
64DoxycyclineDoxycycline241,381-5.65%GenericBacterial infectionsDec-1996Nov-2011
65OrenciaAbatacept241,1491.65%Bristol-Myers Squibb CompanyRheumatoid arthritisAug-2000Mon-20XX
66Amphetamine/dextroamphetamineAmphetamine mixed salts240,4822.78%GenericAttention deficit hyperactivity disorder; narcolepsyFeb-2004Mon-20XX
67VesicareSolifenacin240,4355.37%Astellas Pharma USOveractive bladderFeb-20002018-Nov
68DexilantDexlansoprazole238,8977.57%Takeda Pharmaceuticals North America, IncGastrointestinal disordersDec-2004Jul-2012
69Humalog KwikPenInsulin lispro238,41811.02%Eli Lilly and CompanyDiabetes mellitus type 1 and 2Apr-1996Mon-20XX
70NeupogenFilgrastim229,912-2.70%AmgenNeutropeniaFeb-1991Mon-20XX
71LidocaineLidocaine225,9030.00%GenericPainMar-1999Mon-20XX
72LunestaEszopiclone225,1015.24%GenericInsomniaDec-2004April-2015
73FenofibrateFenofibrate223,300-2.22%GenericCholesterolFeb-1998Mon-20XX
74ZytigaAbiraterone222,02611.86%Janssen Biotech, Inc.Prostate CancerDec-1998April-2015
75ReyatazAtazanavir217,793-1.38%Bristol-Myers SquibbHIV infectionJan-2003Mon-20XX
76SensiparCinacalcet216,65713.71%Amgen Inc.HyperparathyroidismApr-2000Mon-20XX
77MetoprololMetoprolol215,1112.99%GenericHypertensionJan-1992Mon-20XX
78AcipHexRabeprazole214,25110.03%Janssen Pharmaceuticals, Inc, Johnson & JohnsonGastrointestinal disordersAug-1999Nov-2013
79SynthroidLevothyroxine213,424-2.50%GenericHypothyroidismMay-1999Expired
80Avonex PenOlmesartan211,91713.59%Biogen Idec, Forest LaboratoriesHypertensionApr-2002Apr-2016
81Prevnar 13Pneumococcal conjugate vaccine209,3676.41%PfizerPneumococcal diseaseFeb-2000Jan-2007
82XolairOmalizumab207,8911.91%Genentech, NovartisAsthma2003Mon-20XX
83LipitorAtorvastatin207,5424.23%GenericCholesterolDec-1996Nov-2011 [12]
84levothyroxineLevothyroxine204,7550.00%GenericHypothyroidismAug-1990Mon-20XX
85BenicarOlmesartan/hydrochlorothiazide203,3363.22%Daiichi SankyoHypertensionJun-1909Mon-2016
86StribildElvitegravir/cobicistat/emtricitabine/tenofovir202,6420.00%Gilead SciencesHIV/AIDSApr-2000Mon-20XX[13]
87ZostavaxZostavax202,24015.17%Eisai, Merck & Co.Herpes zosterAug-1999May-2013
88PradaxaDabigatran200,697-0.53%Boehringer Ingelheim, Lilly IcosOral anticoagulantOct-2010Mon-20XX
89VytorinEzetimibe/simvastatin199,625-3.02%Merck & Co., Schering-PloughCholesterolJul-2004Mon-20XX
90TamifluOseltamivir197,7180.00%Chugai Pharmaceutical, Hetero Drugs, RocheInfluenzaOct-1999Mon-20XX
91XgevaDenosumab197,7113.24%AmgenOsteoporosisNov-2010Mon-20XX
92EvistaRaloxifene196,929-4.31%Eli Lilly and Company, Chugai PharmaceuticalOsteoporosisDec-1997Jan-2013
93XelodaCapecitabine194,0446.52%GenericCancerJun-1909Mon-20XX [14]
94AranespDarbepoetin alfa185,225-9.22%Amgen Inc.AnemiaJun-2001Mon-20XX
95Ventolin HFASalbutamol183,0600.00%GlaxoSmithKlineAsthma; chronic obstructive pulmonary diseaseMay-1981Mon-20XX
96divalproex sodiumValproate181,5540.00%GenericEpilepsy and bipolar disorder [15]Jun-1909Mon-20XX
97AfinitorEverolimus180,7190.03%NovartisCancerJun-1909Mon-20XX
98Betaseron, BetaferonInterferon beta 1b179,216-3.72%BayerMultiple sclerosisJul-1993Mon-20XX
99Adderall XRAmphetamine mixed salts177,5053.31%GenericAttention deficit hyperactivity disorderOct-2001Mon-20XX
100CompleraEmtricitabine/Rilpivirine/Tenofovir disoproxil fumarate174,9330.00%Gilead Sciences, Inc.HIVJun-20XXMon-20XX

See also

References

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