List of quadrant routes in Lancaster County, Pennsylvania

Quadrant Routes in Pennsylvania are maintained by the Pennsylvania Department of Transportation. This article lists all the routes and their termini in Lancaster County. As is the case with the other counties in the state, the route numbers start in the northeast quadrant and go clockwise from the 1000s to the 4000s. Odd numbered roads travel south to north, with numbering starting in the south and west of the quadrant. Even numbered roads travel west to east, with numbering also starting in the south and west.

The quadrant dividing lines are as follows: North and South are separated by PA 462 from the Susquehanna River to Lancaster and PA 340 from the western terminus to the Chester County line. East and west are separated by US 222 from the Maryland state line to Lancaster and PA 501 from its southern terminus to the Lebanon County line.