Tenascin X

A member of the tenascin family, tenascin X (TN-X) also known as hexabrachion-like protein is a glycoprotein that is expressed in connective tissues including skin, joints and muscles. In humans, tenascin X is encoded by the TNXB gene.[5]

TNXB
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesTNXB, EDS3, HXBL, TENX, TN-X, TNX, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS, tenascin XB, EDSCLL, EDSCLL1
External IDsOMIM: 600985 MGI: 1932137 HomoloGene: 49589 GeneCards: TNXB
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.33-p21.32Start32,041,153 bp[1]
End32,115,334 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

7148

81877

Ensembl

ENSMUSG00000033327

UniProt

P22105

n/a

RefSeq (mRNA)

NM_032470
NM_019105
NM_001365276

NM_031176

RefSeq (protein)

NP_061978
NP_115859
NP_001352205

n/a

Location (UCSC)Chr 6: 32.04 – 32.12 MbChr 17: 34.66 – 34.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene

This gene localizes to the major histocompatibility complex (MHC class III) region on chromosome 6. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively.[6]

Function

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing.[6]

Clinical significance

Deficiency causes Classical-like Ehlers–Danlos syndrome, where collagen density is reduced and elastic fibers are fragmentated.[7]

References

  1. ENSG00000236221, ENSG00000229353, ENSG00000229341, ENSG00000233323, ENSG00000231608, ENSG00000206258, ENSG00000168477 GRCh38: Ensembl release 89: ENSG00000236236, ENSG00000236221, ENSG00000229353, ENSG00000229341, ENSG00000233323, ENSG00000231608, ENSG00000206258, ENSG00000168477 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033327 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tee MK, Thomson AA, Bristow J, Miller WL (July 1995). "Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X". Genomics. 28 (2): 171–8. doi:10.1006/geno.1995.1128. PMID 8530023.
  6. "Entrez Gene: tenascin XB".
  7. Zweers, MC; Schalkwijk, J; Van Kuppevelt, TH; Van Vlijmen-Willems, IM; Bergers, M; Lethias, C; Lamme, EN (2005). "Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components". Cell and Tissue Research. 319 (2): 279–87. doi:10.1007/s00441-004-1011-6. PMID 15558324. S2CID 5889106.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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