1-alkyl-2-acetylglycerophosphocholine esterase

In enzymology, a 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) is an enzyme that catalyzes the chemical reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O 1-alkyl-sn-glycero-3-phosphocholine + acetate
1-alkyl-2-acetylglycerophosphocholine esterase
Identifiers
EC number3.1.1.47
CAS number76901-00-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine and H2O, whereas its two products are 1-alkyl-sn-glycero-3-phosphocholine and acetate. The former is also known as platelet-activating factor. There are multiple enzymes with this function:

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase. Other names in common use include 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, and alkylacetyl-GPC:acetylhydrolase. This enzyme participates in ether lipid metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1BWP, 1BWQ, 1BWR, 1ES9, 1FXW, 1VYH, and 1WAB.

References

    • Blank ML, Lee T, Fitzgerald V, Snyder F (1981). "A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid)". J. Biol. Chem. 256 (1): 175–8. PMID 7451433.


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