CCL8

Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene.[3][4]

CCL8
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1ESR
Identifiers
Aliases	CCL8, HC14, MCP-2, MCP2, SCYA10, SCYA8, C-C motif chemokine ligand 8
External IDs	OMIM: 602283 HomoloGene: 48362 GeneCards: CCL8
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 34,319,435 bp[1] End 34,321,402 bp[1]
Gene ontology Molecular function • protein kinase activity • cytokine activity • heparin binding • phospholipase activator activity • CCR chemokine receptor binding • chemokine activity • GO:0001948 protein binding • CCR2 chemokine receptor binding Cellular component • extracellular region • extracellular Biological process • G-protein coupled receptor signaling pathway • monocyte chemotaxis • chemokine-mediated signaling pathway • cellular response to tumor necrosis factor • cell-cell signaling • response to virus • cellular calcium ion homeostasis • neutrophil chemotaxis • chemotaxis • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cellular response to interleukin-1 • immune response • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • lymphocyte chemotaxis • inflammatory response • calcium ion transport • signal transduction • exocytosis • protein phosphorylation • antimicrobial humoral immune response mediated by antimicrobial peptide • positive regulation of leukocyte migration • negative regulation of leukocyte proliferation • regulation of receptor activity • angiogenesis • eosinophil chemotaxis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6355	n/a
Ensembl	ENSG00000108700	n/a
UniProt	P80075	n/a
RefSeq (mRNA)	NM_005623	n/a
RefSeq (protein)	NP_005614	n/a
Location (UCSC)	Chr 17: 34.32 – 34.32 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

CCL8 is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans.[4][5] MCP-2 is chemotactic for and activates many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response.[6][7] CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B, CCR3 and CCR5.[7][8]

CCL8 is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes. CCL8 is a potent inhibitor of HIV1 by virtue of its high-affinity binding to the receptor CCR5, one of the major co-receptors for HIV1.[9] In addition, CCL8 attributes to the growth of metastasis in breast cancer cells. The manipulation of this chemokine activity influences the histology of tumors promoting steps of metastatic processes.[10] CCL8 is also involved in attracting macrophages to the decidua in labor.[11]