CXCL11

C-X-C motif chemokine 11 (CXCL11) is a protein that in humans is encoded by the CXCL11 gene.[3]

CXCL11
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1RJT
Identifiers
Aliases	CXCL11, H174, I-TAC, IP-9, IP9, SCYB11, SCYB9B, b-R1, C-X-C motif chemokine ligand 11
External IDs	OMIM: 604852 HomoloGene: 3944 GeneCards: CXCL11
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 76,033,682 bp[1] End 76,041,415 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • chemokine activity • cytokine activity • heparin binding • GO:0001948 protein binding • CXCR3 chemokine receptor binding Cellular component • extracellular region • extracellular • intracellular Biological process • chemotaxis • positive regulation of leukocyte chemotaxis • T cell chemotaxis • chemokine-mediated signaling pathway • response to lipopolysaccharide • cell-cell signaling • positive regulation of release of sequestered calcium ion into cytosol • positive regulation of cAMP-mediated signaling • regulation of cell proliferation • immune response • signal transduction • defense response • inflammatory response • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of receptor activity • G-protein coupled receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • neutrophil chemotaxis • leukocyte chemotaxis • cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6373	n/a
Ensembl	ENSG00000169248	n/a
UniProt	O14625	n/a
RefSeq (mRNA)	NM_005409 NM_001302123	n/a
RefSeq (protein)	NP_001289052 NP_005400	n/a
Location (UCSC)	Chr 4: 76.03 – 76.04 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.[4]

Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α.[5] This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10.[4][6] CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.[7][8]