CXCL13

CXCL13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ZAI, 5CBA, 5CBE
Identifiers
Aliases	CXCL13, ANGIE, ANGIE2, BCA-1, BCA1, BLC, BLR1L, SCYB13, C-X-C motif chemokine ligand 13
External IDs	OMIM: 605149 MGI: 1888499 HomoloGene: 48431 GeneCards: CXCL13
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	77,611,834 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	95,961,068 bp[2]
Gene ontology
Molecular function	• receptor ligand activity; • CCR10 chemokine receptor binding; • cytokine activity; • heparin binding; • CXCR3 chemokine receptor binding; • chemokine activity; • protein heterodimerization activity; • fibroblast growth factor binding; • CXCR5 chemokine receptor binding;
Cellular component	• extracellular region; • extracellular;
Biological process	• chemokine-mediated signaling pathway; • positive regulation of cytosolic calcium ion concentration; • cell-cell signaling; • germinal center formation; • regulation of angiogenesis; • chemotaxis; • endothelial cell chemotaxis to fibroblast growth factor; • regulation of humoral immune response; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • regulation of cell proliferation; • defense response to bacterium; • negative regulation of endothelial cell chemotaxis to fibroblast growth factor; • positive regulation of T cell chemotaxis; • immune response; • inflammatory response; • chronic inflammation; • defense response; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of receptor activity; • G-protein coupled receptor signaling pathway; • lymphocyte chemotaxis across high endothelial venule; • positive regulation of integrin activation; • positive regulation of cell-cell adhesion mediated by integrin; • B cell chemotaxis; • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity; • neutrophil chemotaxis; • leukocyte chemotaxis; • cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	10563
	55985
	ENSG00000156234
	ENSMUSG00000023078
	O43927
	O55038
	NM_006419; NM_001371558
	NM_018866
	NP_006410; NP_001358487
	NP_061354
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene.[5][6]

Function

CXCL13 is a small chemokine belonging to the CXC chemokine family. As its other names suggest, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5.[5][7] CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues.[8] and is expressed highly in the liver, spleen, lymph nodes, and gut of humans.[5] The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines.[6]

In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or T_FH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as Angioimmunoblastic T-cell Lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.[9]

References

GRCh38: Ensembl release 89: ENSG00000156234 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000023078 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (February 1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416.
Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (February 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. doi:10.1038/35876. PMID 9486651. S2CID 4373691.
Ansel KM, Harris RB, Cyster JG (January 2002). "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity". Immunity. 16 (1): 67–76. doi:10.1016/S1074-7613(01)00257-6. PMID 11825566.
Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG (July 2000). "A chemokine-driven positive feedback loop organizes lymphoid follicles". Nature. 406 (6793): 309–14. doi:10.1038/35018581. PMID 10917533. S2CID 4369622.
de Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (June 2007). "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells". Blood. 109 (11): 4952–63. doi:10.1182/blood-2006-10-055145. PMID 17284527.

External links

Human CXCL13 genome location and CXCL13 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: O43927 (C-X-C motif chemokine 13) at the PDBe-KB.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156234 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023078 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9463416-5] Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (February 1998). "B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5". J. Exp. Med. 187 (4): 655–60. doi:10.1084/jem.187.4.655. PMC 2212150. PMID 9463416.

[pmid9486651-6] Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (February 1998). "A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1". Nature. 391 (6669): 799–803. doi:10.1038/35876. PMID 9486651. S2CID 4373691.

[pmid11825566-7] Ansel KM, Harris RB, Cyster JG (January 2002). "CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity". Immunity. 16 (1): 67–76. doi:10.1016/S1074-7613(01)00257-6. PMID 11825566.

[pmid10917533-8] Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG (July 2000). "A chemokine-driven positive feedback loop organizes lymphoid follicles". Nature. 406 (6793): 309–14. doi:10.1038/35018581. PMID 10917533. S2CID 4369622.

[pmid17284527-9] Leval L, Rickman DS, Thielen C, Reynies A, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P (June 2007). "The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells". Blood. 109 (11): 4952–63. doi:10.1182/blood-2006-10-055145. PMID 17284527.