CLTC

CLTC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XZG, 4G55
Identifiers
Aliases	CLTC, CHC, CHC17, CLH-17, CLTCL2, Hc, clathrin heavy chain, MRD56
External IDs	OMIM: 118955 MGI: 2388633 HomoloGene: 3572 GeneCards: CLTC
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	59,696,956 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	86,757,565 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • double-stranded RNA binding; • protein kinase binding; • structural molecule activity; • RNA binding; • clathrin light chain binding; • disordered domain specific binding; • low-density lipoprotein particle receptor binding; • ubiquitin-specific protease binding;
Cellular component	• extracellular vesicle; • cytosol; • clathrin-coated endocytic vesicle membrane; • clathrin coat of coated pit; • trans-Golgi network membrane; • clathrin coat of trans-Golgi network vesicle; • focal adhesion; • melanosome; • cell membrane; • endolysosome membrane; • clathrin-coated pit; • extracellular exosome; • cytoplasmic vesicle membrane; • cytoplasmic vesicle; • clathrin-coated vesicle; • extracellular matrix; • membrane; • mitotic spindle microtubule; • cytoplasm; • lysosome; • endosome; • spindle; • cytoskeleton; • clathrin coat; • clathrin complex; • macromolecular complex; • intracellular membrane-bounded organelle; • clathrin-coated endocytic vesicle; • mitotic spindle; • intracellular;
Biological process	• antigen processing and presentation of exogenous peptide antigen via MHC class II; • transferrin transport; • receptor internalization; • negative regulation of protein localization to plasma membrane; • retrograde transport, endosome to Golgi; • osteoblast differentiation; • vesicle-mediated transport; • negative regulation of hyaluronan biosynthetic process; • intracellular protein transport; • Wnt signaling pathway, planar cell polarity pathway; • regulation of mitotic spindle organization; • autophagy; • microtubule-based movement; • cell cycle; • cell division; • membrane organization; • GO:0007067 mitotic cell cycle; • receptor-mediated endocytosis; • low-density lipoprotein particle receptor catabolic process; • low-density lipoprotein particle clearance; • clathrin coat assembly; • clathrin-dependent endocytosis; • amyloid-beta clearance by transcytosis;
	Sources:Amigo / QuickGO
Orthologs
	1213
	67300
	ENSG00000141367
	ENSMUSG00000047126
	Q00610
	Q68FD5
	NM_001288653; NM_004859
	NM_001003908; NM_001356393
	NP_001275582; NP_004850
	NP_001003908; NP_001343322
	Wikidata
View/Edit Human	View/Edit Mouse

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.[5][6]

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.[7] }}

Interactions

CLTC has been shown to interact with PICALM[8] and HGS.[9]

References

GRCh38: Ensembl release 89: ENSG00000141367 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000047126 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Dodge GR, Kovalszky I, McBride OW, Yi HF, Chu ML, Saitta B, Stokes DG, Iozzo RV (Feb 1992). "Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter". Genomics. 11 (1): 174–8. doi:10.1016/0888-7543(91)90115-U. PMID 1765375.
Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
"Entrez Gene: CLTC clathrin, heavy chain (Hc)".
Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Mol. Biol. Cell. 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. ISSN 1059-1524. PMC 25500. PMID 10436022.
Raiborg, C; Bache K G; Mehlum A; Stang E; Stenmark H (Sep 2001). "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. ISSN 0261-4189. PMC 125612. PMID 11532964.

External links

Human CLTC genome location and CLTC gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141367 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047126 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1765375-5] Dodge GR, Kovalszky I, McBride OW, Yi HF, Chu ML, Saitta B, Stokes DG, Iozzo RV (Feb 1992). "Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter". Genomics. 11 (1): 174–8. doi:10.1016/0888-7543(91)90115-U. PMID 1765375.

[pmid7584026-6] Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.

[7] "Entrez Gene: CLTC clathrin, heavy chain (Hc)".

[pmid10436022-8] Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Mol. Biol. Cell. 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. ISSN 1059-1524. PMC 25500. PMID 10436022.

[pmid11532964-9] Raiborg, C; Bache K G; Mehlum A; Stang E; Stenmark H (Sep 2001). "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. ISSN 0261-4189. PMC 125612. PMID 11532964.

CLTC

Interactions

See also

References

Further reading

External links