RAB3A

Ras-related protein Rab-3A is a protein that in humans is encoded by the RAB3A gene.[5][6][7] It is involved in calcium-triggered exocytosis in neurons.

RAB3A
Identifiers
AliasesRAB3A, member RAS oncogene family
External IDsOMIM: 179490 MGI: 97843 HomoloGene: 20629 GeneCards: RAB3A
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.11Start18,196,784 bp[1]
End18,204,042 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5864

19339

Ensembl

ENSG00000105649

ENSMUSG00000031840

UniProt

P20336

P63011

RefSeq (mRNA)

NM_002866

NM_001166399
NM_009001
NM_001328047

RefSeq (protein)

NP_002857
NP_002857.1

NP_001159871
NP_001314976
NP_033027
NP_001365821
NP_001365822

Location (UCSC)Chr 19: 18.2 – 18.2 MbChr 8: 70.75 – 70.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

RAB3A has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000105649 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031840 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rousseau-Merck MF, Zahraoui A, Bernheim A, Touchot N, Miglierina R, Tavitian A, Berger R (January 1990). "Chromosome mapping of the human ras-related rab3A gene to 19p13.2". Genomics. 5 (4): 694–8. doi:10.1016/0888-7543(89)90110-9. PMID 2687157.
  6. Brondyk WH, McKiernan CJ, Fortner KA, Stabila P, Holz RW, Macara IG (March 1995). "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A". Mol Cell Biol. 15 (3): 1137–43. doi:10.1128/MCB.15.3.1137. PMC 230335. PMID 7532276.
  7. "Entrez Gene: RAB3A RAB3A, member RAS oncogene family".
  8. Fukuda M (April 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
  9. Betz A, Thakur P, Junge HJ, Ashery U, Rhee JS, Scheuss V, Rosenmund C, Rettig J, Brose N (April 2001). "Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming". Neuron. 30 (1): 183–96. doi:10.1016/s0896-6273(01)00272-0. hdl:11858/00-001M-0000-0012-F596-C. PMID 11343654. S2CID 155875.
  10. "Protein unc-13 homolog A". UniProt.
  11. Ostermeier C, Brunger AT (February 1999). "Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A". Cell. 96 (3): 363–74. doi:10.1016/S0092-8674(00)80549-8. PMID 10025402. S2CID 15162326.
  12. Weber E, Jilling T, Kirk KL (March 1996). "Distinct functional properties of Rab3A and Rab3B in PC12 neuroendocrine cells". J. Biol. Chem. 271 (12): 6963–71. doi:10.1074/jbc.271.12.6963. PMID 8636125.
  13. Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (January 1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene". J. Biol. Chem. 269 (3): 2111–7. PMID 8294464.
  14. Pereira-Leal JB, Strom M, Godfrey RF, Seabra MC (January 2003). "Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface". Biochem. Biophys. Res. Commun. 301 (1): 92–7. doi:10.1016/s0006-291x(02)02963-7. PMID 12535645.

Further reading


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