STX1B

STX1B
Identifiers
Aliases	STX1B, STX1B1, STX1B2, GEFSP9, syntaxin 1B
External IDs	OMIM: 601485 MGI: 1930705 HomoloGene: 69375 GeneCards: STX1B
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	31,010,638 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	127,824,549 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• SNAP receptor activity; • protein kinase binding; • receptor binding; • SNARE binding; • protein domain specific binding;
Cellular component	• integral component of membrane; • cytosol; • membrane; • synaptic vesicle; • cell membrane; • spindle; • microtubule organizing center; • SNARE complex; • cytoskeleton; • nuclear lamina; • cell nucleus; • nucleoplasm; • centrosome; • cytoplasm; • presynaptic membrane; • presynapse; • presynaptic active zone membrane; • axon; • neuromuscular junction; • endomembrane system;
Biological process	• synaptic vesicle docking; • spontaneous neurotransmitter secretion; • positive regulation of neurotransmitter secretion; • regulation of exocytosis; • vesicle docking; • positive regulation of excitatory postsynaptic potential; • regulation of gene expression; • protein transport; • intracellular protein transport; • neurotransmitter transport; • vesicle-mediated transport; • regulation of synaptic vesicle priming; • negative regulation of neuron projection development; • regulation of synaptic activity; • vesicle docking involved in exocytosis; • calcium ion-regulated exocytosis of neurotransmitter; • protein localization to membrane; • negative regulation of synaptic vesicle recycling; • positive regulation of spontaneous neurotransmitter secretion; • negative regulation of macropinocytosis; • synaptic vesicle fusion to presynaptic active zone membrane; • exocytic insertion of neurotransmitter receptor to postsynaptic membrane; • synaptic vesicle exocytosis; • exocytosis; • vesicle fusion;
	Sources:Amigo / QuickGO
Orthologs
	112755
	56216
	ENSG00000099365
	ENSMUSG00000030806
	P61266
	P61264
	NM_052874
	NM_024414
	NP_443106
	NP_077725
	Wikidata
View/Edit Human	View/Edit Mouse

Syntaxin-1B is a protein that in humans is encoded by the STX1B gene.[5]

Interactions

STX1B has been shown to interact with UNC13B.[6]

References

GRCh38: Ensembl release 89: ENSG00000099365 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030806 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: STX1B2 syntaxin 1B2".
Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.

Li G, Alexander EA, Schwartz JH (May 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". The Journal of Biological Chemistry. 278 (22): 19791–7. doi:10.1074/jbc.M212250200. PMID 12651853.
Pérez-Brangulí F, Muhaisen A, Blasi J (June 2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Molecular and Cellular Neurosciences. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152. S2CID 23927545.
Nagamatsu S, Nakamichi Y, Watanabe T, Matsushima S, Yamaguchi S, Ni J, Itagaki E, Ishida H (January 2001). "Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules". Journal of Cell Science. 114 (Pt 1): 219–227. PMID 11112705.
Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.
Smirnova T, Miniou P, Viegas-Pequignot E, Mallet J (September 1996). "Assignment of the human syntaxin 1B gene (STX) to chromosome 16p11.2 by fluorescence in situ hybridization". Genomics. 36 (3): 551–3. doi:10.1006/geno.1996.0506. PMID 8884284.
Smirnova T, Stinnakre J, Mallet J (October 1993). "Characterization of a presynaptic glutamate receptor". Science. 262 (5132): 430–3. doi:10.1126/science.8105537. PMID 8105537.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099365 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030806 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: STX1B2 syntaxin 1B2".

[pmid8999968-6] Betz A, Okamoto M, Benseler F, Brose N (January 1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin". The Journal of Biological Chemistry. 272 (4): 2520–6. doi:10.1074/jbc.272.4.2520. PMID 8999968.

STX1B

Interactions

References

Further reading