OR11H4

Olfactory receptor 11H4 is a protein that in humans is encoded by the OR11H4 gene.[5]

OR11H4
Identifiers
AliasesOR11H4, OR14-36, olfactory receptor family 11 subfamily H member 4
External IDsMGI: 3030583 HomoloGene: 10652 GeneCards: OR11H4
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q11.2Start20,239,286 bp[1]
End20,244,349 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

390442

56858

Ensembl

ENSG00000176198

ENSMUSG00000059069

UniProt

Q8NGC9

E9Q438

RefSeq (mRNA)

NM_001004479

NM_020288

RefSeq (protein)

NP_001004479

NP_064684

Location (UCSC)Chr 14: 20.24 – 20.24 MbChr 14: 50.74 – 50.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

  • Isovaleric acid[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000176198 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000059069 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: OR11H4 olfactory receptor, family 11, subfamily H, member 4".
  6. Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D (October 2007). "Genetic elucidation of human hyperosmia to isovaleric acid". PLOS Biology. 5 (11): e284. doi:10.1371/journal.pbio.0050284. PMC 2043052. PMID 17973576.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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