OR56A4

OR56A4
Identifiers
Aliases	OR56A4, OR11-49, olfactory receptor family 56 subfamily A member 4
External IDs	MGI: 3030518 HomoloGene: 133596 GeneCards: OR56A4
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	6,006,946 bp[1]
Gene ontology
Molecular function	• G-protein coupled receptor activity; • olfactory receptor activity; • signal transducer activity; • adrenergic receptor activity; • dopamine neurotransmitter receptor activity, coupled via Gi/Go; • dopamine binding;
Cellular component	• integral component of membrane; • cell membrane; • integral component of plasma membrane; • membrane; • synaptic vesicle membrane;
Biological process	• adenylate cyclase-activating adrenergic receptor signaling pathway; • sensory perception of smell; • detection of chemical stimulus involved in sensory perception of smell; • signal transduction; • response to stimulus; • synaptic transmission, dopaminergic; • negative regulation of adenylate cyclase activity; • adenylate cyclase-inhibiting dopamine receptor signaling pathway; • response to toxic substance; • regulation of dopamine secretion; • response to drug; • regulation of potassium ion transport; • behavioral response to cocaine; • behavioral response to ethanol; • negative regulation of cytosolic calcium ion concentration; • negative regulation of synaptic transmission, glutamatergic; • phospholipase C-activating dopamine receptor signaling pathway; • negative regulation of voltage-gated calcium channel activity; • G-protein coupled receptor signaling pathway; • adrenergic receptor signaling pathway; • adenylate cyclase-modulating G-protein coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	120793
	244187
	ENSG00000183389
	ENSMUSG00000047225
	Q8NGH8
	Q7TRN8
	NM_001005179
	NM_207249
	NP_001005179
	NP_997132
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 56A4 is a protein that in humans is encoded by the OR56A4 gene.[4]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

Ligands

References

GRCh38: Ensembl release 89: ENSG00000183389 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: OR56A4 olfactory receptor, family 56, subfamily A, member 4".
Adipietro KA, Mainland JD, Matsunami H (2012). "Functional evolution of mammalian odorant receptors". PLOS Genetics. 8 (7): e1002821. doi:10.1371/journal.pgen.1002821. PMC 3395614. PMID 22807691.
Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC 3990440. PMID 24316890.

External links

OR56A4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183389 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: OR56A4 olfactory receptor, family 56, subfamily A, member 4".

[pmid22807691-5] Adipietro KA, Mainland JD, Matsunami H (2012). "Functional evolution of mammalian odorant receptors". PLOS Genetics. 8 (7): e1002821. doi:10.1371/journal.pgen.1002821. PMC 3395614. PMID 22807691.

[6] Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC 3990440. PMID 24316890.

OR56A4

Ligands

See also

References

Further reading

External links