OR2W1

Olfactory receptor 2W1 is a protein that in humans is encoded by the OR2W1 gene.[4]

OR2W1
Identifiers
AliasesOR2W1, hs6M1-15, olfactory receptor family 2 subfamily W member 1
External IDsMGI: 3030097 HomoloGene: 12791 GeneCards: OR2W1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p22.1Start29,044,213 bp[1]
End29,045,240 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

26692

18341

Ensembl

ENSMUSG00000071522

UniProt

Q9Y3N9

Q7TQT8

RefSeq (mRNA)

NM_030903

NM_010984

RefSeq (protein)

NP_112165

NP_035114

Location (UCSC)Chr 6: 29.04 – 29.05 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

Ligands

Out of 10 human ORs studied, OR2W1 was the most broadly tuned, meaning it responds to the greatest variety of different odorant molecules.[5]

Ligands, in decreasing order of sensitivity:[5]

See also

References
  1. ENSG00000226463, ENSG00000206525, ENSG00000228977, ENSG00000228652, ENSG00000229328, ENSG00000227639, ENSG00000234101 GRCh38: Ensembl release 89: ENSG00000204704, ENSG00000226463, ENSG00000206525, ENSG00000228977, ENSG00000228652, ENSG00000229328, ENSG00000227639, ENSG00000234101 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: OR2W1 olfactory receptor, family 2, subfamily W, member 1".
  5. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.
  6. Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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