OR2M3

Olfactory receptor 2M3 is a protein that in humans is encoded by the OR2M3 gene.[4]

OR2M3
Identifiers
AliasesOR2M3, OR1-54, OR2M3P, OR2M6, OST003, olfactory receptor family 2 subfamily M member 3
External IDsMGI: 3029998 HomoloGene: 51725 GeneCards: OR2M3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q44Start248,197,265 bp[1]
End248,212,925 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

127062

258443

Ensembl

ENSG00000228198

ENSMUSG00000050742

UniProt

Q8NG83

Q8VF87

RefSeq (mRNA)

NM_001004689

NM_146451

RefSeq (protein)

NP_001004689

NP_666662

Location (UCSC)Chr 1: 248.2 – 248.21 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[4]

OR2M3 has a copper binding pocket.[5]

Ligands
  • 3-Mercapto-2-methylpentan-1-ol [6]

This chemical is associated with characteristic smell of raw onions.

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000228198 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: OR2M3 olfactory receptor, family 2, subfamily M, member 3".
  5. Haag F, Ahmed L, Reiss K, Block E, Batista VS, Krautwurst D (August 2019). "Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3". Cellular and Molecular Life Sciences. 77 (11): 2157–2179. doi:10.1007/s00018-019-03279-y. PMC 7256108. PMID 31435697.
  6. Noe F, Polster J, Geithe C, Kotthoff M, Schieberle P, Krautwurst D (March 2017). "OR2M3: A Highly Specific and Narrowly Tuned Human Odorant Receptor for the Sensitive Detection of Onion Key Food Odorant 3-Mercapto-2-methylpentan-1-ol". Chemical Senses. 42 (3): 195–210. doi:10.1093/chemse/bjw118. PMID 27916748.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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