Streptolysin

Streptolysins are two hemolytic exotoxins from Streptococcus.[1][2] Types include streptolysin O (SLO; slo), which is oxygen-labile, and streptolysin S (SLS; sagA), which is oxygen-stable.[3]

Streptolysin O
Identifiers
OrganismStreptococcus pyogenes serotype M1
Symbolslo
UniProtP0C0I3
Streptolysin S
Identifiers
OrganismStreptococcus pyogenes serotype M4 (strain MGAS10750)
SymbolsagA
UniProtQ1J7I0

SLO is part of the thiol-activated cytolysin family.[4] It is hemolytically active only in a reversibly reduced state. It is antigenic, so its antibody antistreptolysin O can be detected in an antistreptolysin O titre.

SLS is stable in the presense of oxygen. It is not antigenic due to its small size. It is sometimes considered a bacteriocin due to similarities in the synthesis pathway.[5]

References
  1. "streptolysin" at Dorland's Medical Dictionary
  2. Streptolysin at the US National Library of Medicine Medical Subject Headings (MeSH)
  3. Sierig G, Cywes C, Wessels MR, Ashbaugh CD (January 2003). "Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorly encapsulated group a streptococci". Infection and Immunity. 71 (1): 446–55. doi:10.1128/IAI.71.1.446-455.2003. PMC 143243. PMID 12496195.
  4. Billington SJ, Jost BH, Songer JG (January 2000). "Thiol-activated cytolysins: structure, function and role in pathogenesis". FEMS Microbiology Letters. 182 (2): 197–205. doi:10.1111/j.1574-6968.2000.tb08895.x. PMID 10620666.
  5. Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, et al. (April 2008). "Discovery of a widely distributed toxin biosynthetic gene cluster". Proceedings of the National Academy of Sciences of the United States of America. 105 (15): 5879–84. doi:10.1073/pnas.0801338105. PMC 2311365. PMID 18375757.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.