PGDS

PGDS protein is a protein that in humans is encoded by the HPGDS gene.[5][6][7][8]

HPGDS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHPGDS, GSTS, GSTS1-1, PGD2, PGDS, GSTS1, hematopoietic prostaglandin D synthase
External IDsOMIM: 602598 MGI: 1859384 HomoloGene: 113741 GeneCards: HPGDS
EC number2.5.1.18
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q22.3Start94,298,535 bp[1]
End94,342,876 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

27306

54486

Ensembl

ENSG00000163106

ENSMUSG00000029919

UniProt

O60760

Q9JHF7

RefSeq (mRNA)

NM_014485

NM_019455

RefSeq (protein)

NP_055300

NP_062328

Location (UCSC)Chr 4: 94.3 – 94.34 MbChr 6: 65.12 – 65.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.[8]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000163106 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029919 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kanaoka Y, Ago H, Inagaki E, Nanayama T, Miyano M, Kikuno R, Fujii Y, Eguchi N, Toh H, Urade Y, Hayaishi O (Oct 1997). "Cloning and crystal structure of hematopoietic prostaglandin D synthase". Cell. 90 (6): 1085–95. doi:10.1016/S0092-8674(00)80374-8. PMID 9323136. S2CID 933875.
  6. Mahmud I, Ueda N, Yamaguchi H, Yamashita R, Yamamoto S, Kanaoka Y, Urade Y, Hayaishi O (Dec 1997). "Prostaglandin D synthase in human megakaryoblastic cells". J Biol Chem. 272 (45): 28263–6. doi:10.1074/jbc.272.45.28263. PMID 9353279.
  7. Jowsey IR, Thomson AM, Flanagan JU, Murdock PR, Moore GB, Meyer DJ, Murphy GJ, Smith SA, Hayes JD (Oct 2001). "Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases". Biochem J. 359 (Pt 3): 507–16. doi:10.1042/0264-6021:3590507. PMC 1222171. PMID 11672424.
  8. "Entrez Gene: PGDS prostaglandin D2 synthase, hematopoietic".

Further reading

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