Unoprostone

Unoprostone (INN) is a prostaglandin analogue. Its isopropyl ester, unoprostone isopropyl, was marketed under the trade name Rescula for the management of open-angle glaucoma and ocular hypertension.[1]

Unoprostone

Clinical data
Trade names	Rescula
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of administration	Topical (eye drops)
ATC code	S01EE02 (WHO)
Legal status
Legal status	US: Discontinued
Pharmacokinetic data
Elimination half-life	14 min
Excretion	Renal
Identifiers
IUPAC name (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl) cyclopentyl]hept-5-enoic acid
CAS Number	120373-36-6 Y 120373-24-2 (isopropyl ester)
PubChem CID	5311236
DrugBank	DB06826 N
ChemSpider	4470755 N
UNII	6X4F561V3W
KEGG	D08661 Y
ChEMBL	ChEMBL1201407 N
CompTox Dashboard (EPA)	DTXSID80905120
ECHA InfoCard	100.227.145
Chemical and physical data
Formula	C22H38O5
Molar mass	382.541 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(=O)CCCCCCC
InChI InChI=1S/C22H38O5/c1-2-3-4-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27/h6,9,18-21,24-25H,2-5,7-8,10-16H2,1H3,(H,26,27)/b9-6-/t18-,19-,20+,21-/m1/s1 N Key:TVHAZVBUYQMHBC-SNHXEXRGSA-N N
NY (what is this?)  (verify)

It was approved by the Food and Drug Administration in 2000.[2]

In 2009, Sucampo Pharmaceuticals acquired the rights to the drug in the U.S. and Canada.[3]

In 2015, the drug was discontinued in the U.S.